Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ABCC3 (O15438) - Overview - Molecular Target Synopsis

Protein


ABCC3, Canalicular multispecific organic anion transporter 2
UniProt O15438

Also Known as MRP3_HUMAN, ABCC3, CMOAT2, MLP2, MRP3

May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ABCC3 is active in the following subcellular-locations: membrane.
GO terms: ABCC3 is active in the following subcellular-locations: integral component of plasma membrane, membrane, plasma membrane, vacuolar membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ABCC3 has gain in 5 cell-lines, loss in 0 cell-lines and no signal in 998 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: A549, OVCAR_5, HT29

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SNU-5, WiDr, HT-29

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, A549, HMEC

(see details)

3D Structures


At greater than 50% identity similarity to ABCC3 there are:
7 structures (8 chains) solved
4 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

ABCC3 is solved in complex with the approved drug(s):

CLR/CHOLESTEROL (6BHU_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ABCC3 has been screened with 35 compounds (83 bioactivities). (see details)