Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SLC16A3 (O15427) - Overview - Molecular Target Synopsis

Protein


SLC16A3, Monocarboxylate transporter 4
UniProt O15427

Also Known as MOT4_HUMAN, SLC16A3, MCT4

Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: SLC16A3 is active in the following subcellular-locations: cell membrane.
GO terms: SLC16A3 is active in the following subcellular-locations: integral component of plasma membrane, integral component of postsynaptic density membrane, membrane, nuclear membrane, parallel fiber to Purkinje cell synapse, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SLC16A3 has gain in 2 cell-lines, loss in 1 cell-lines and no signal in 998 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: CAKI_1, SF_539, SR

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: G120, G84, NCI-H2595

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: IMR-90, HMEC, BJ

(see details)


Screening and Chemistry


SLC16A3 has been screened with 42 compounds (49 bioactivities), 2 compounds have bioactivities that show binding affinity of <= 500nM (3 bioactivities). (see details)