Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

BCAT2 (O15382) - Overview - Molecular Target Synopsis

Protein


BCAT2, Branched-chain-amino-acid aminotransferase, mitochondrial
Enzyme Classification 2.6.1.42
UniProt O15382

Also Known as BCAT2_HUMAN, BCAT2, BCATM, BCT2, ECA40

Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. May also function as a transporter of branched chain alpha-keto acids. Homodimer.

5MPR
SINGLE AMINO ACID VARIANT OF HUMAN MITOCHONDRIAL BRANCHED CHAIN AMINO ACID AMINOTRANSFERASE 2
RCSB/PDB
Inspect Structure
See all 3D Structures for BCAT2

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: BCAT2 is active in the following subcellular-locations: cytoplasm, mitochondrion.
GO terms: BCAT2 is active in the following subcellular-locations: mitochondrial matrix, mitochondrion.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project BCAT2 has gain in 2 cell-lines, loss in 2 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HCT_15, A549, HL_60

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: RT4, SW 780, SCLC-22H

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, A549, HeLa-S3

(see details)

3D Structures


For BCAT2 there are:
28 structures (55 chains) solved
28 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

BCAT2 is solved in complex with the approved drug(s):

GBN/GABAPENTIN (2A1H_A, 2A1H_B).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


BCAT2 has been screened with compounds ( bioactivities). (see details)