Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SLC16A5 (O15375) - Overview - Molecular Target Synopsis

Protein


SLC16A5, Monocarboxylate transporter 6
UniProt O15375

Also Known as MOT6_HUMAN, SLC16A5, MCT5, MCT6

Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: SLC16A5 is active in the following subcellular-locations: cell membrane.
GO terms: SLC16A5 is active in the following subcellular-locations: integral component of plasma membrane, membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SLC16A5 has gain in 5 cell-lines, loss in 0 cell-lines and no signal in 999 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HT29, NCI_H322M, T47D

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SNU-5, JHH-1, MDA-MB-361

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: A549, HeLa-S3, HUVEC

(see details)


Screening and Chemistry


SLC16A5 has been screened with compounds ( bioactivities). (see details)