Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ALOX15B (O15296) - Overview - Molecular Target Synopsis

Protein


ALOX15B, Arachidonate 15-lipoxygenase B
Enzyme Classification 1.13.11.33
UniProt O15296

Also Known as LX15B_HUMAN, ALOX15B

Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid to 15S-hydroperoxyeicosatetraenoic acid/(15S)-HPETE. Also acts on linoleic acid to produce 13-hydroxyoctadecadienoic acid/13-HPODE. Has no detectable 8S-lipoxygenase activity but reacts with (8S)-HPETE to produce (8S,15S)-diHPETE. May regulate progression through the cell cycle and cell proliferation. May also regulate cytokine secretion by macrophages and therefore play a role in the immune response. May also regulate macrophage differentiation into proatherogenic foam cells.

4NRE
THE STRUCTURE OF HUMAN 15-LIPOXYGENASE-2 WITH A SUBSTRATE MIMIC
RCSB/PDB
Inspect Structure
See all 3D Structures for ALOX15B

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ALOX15B is active in the following subcellular-locations: cell membrane, cytoplasm, cytoskeleton, cytosol, membrane, nucleus.
GO terms: ALOX15B is active in the following subcellular-locations: cytoskeleton, cytosol, extracellular exosome, extrinsic component of membrane, intracellular, membrane, nucleus, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ALOX15B has gain in 0 cell-lines, loss in 7 cell-lines and no signal in 997 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MOLT_4, UACC_62, TK_10

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: EVSA-T, MDA-MB-361, MDA-MB-415

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HMEC, NHEK, SK-N-SH

(see details)

3D Structures


For ALOX15B there are:
1 structures (1 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ALOX15B has been screened with 97 compounds (125 bioactivities), 4 compounds have bioactivities that show binding affinity of <= 500nM (4 bioactivities). (see details)