Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

GSTA4 (O15217) - Overview - Molecular Target Synopsis

Protein


GSTA4, Glutathione S-transferase A4
Enzyme Classification 2.5.1.18
UniProt O15217

Also Known as GSTA4_HUMAN, GSTA4

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. This isozyme has a high catalytic efficiency with 4-hydroxyalkenals such as 4-hydroxynonenal (4-HNE). Homodimer.

3IK7
HUMAN GLUTATHIONE TRANSFERASE A4-4 WITH GSDHN
RCSB/PDB
Inspect Structure
See all 3D Structures for GSTA4

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: GSTA4 is active in the following subcellular-locations: cytoplasm.
GO terms: GSTA4 is active in the following subcellular-locations: cytosol.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project GSTA4 has gain in 5 cell-lines, loss in 1 cell-lines and no signal in 999 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: NCI_H522, SNB_75, SF_268

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H510A, NCI-H209, NCI-H1581

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, SK-N-SH, AG445

(see details)

3D Structures


For GSTA4 there are:
3 structures (20 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


GSTA4 has been screened with 4 compounds (4 bioactivities). (see details)