Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

EPHB6 (O15197) - Overview - Molecular Target Synopsis

Protein


EPHB6, Ephrin type-B receptor 6
UniProt O15197

Also Known as EPHB6_HUMAN, EPHB6

Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2. Interacts with CBL and EPHB1. Interacts with FYN; this interaction takes place in a ligand-independent manner.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
1021ENSG00000106123ENST00000392957, ENST00000442129ENSP00000376684, ENSP00000410789O15197-1
744O15197-2
540O15197-3

Drugs


EPHB6 is targeted by Approved Drug Vandetanib. (see details)
Vandetanib

Sub-cellular localization


UniProt: EPHB6 is active in the following subcellular-locations: membrane, secreted.
GO terms: EPHB6 is active in the following subcellular-locations: cytosol, extracellular region, integral component of plasma membrane, neuron projection, plasma membrane, receptor complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project EPHB6 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: CCRF_CEM, COLO205, MOLT_4

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: OCUM-1, JHH-2, COLO 206F

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: K562, SK-N-SH, NHLF

(see details)

3D Structures


At greater than 50% identity similarity to EPHB6 there are:
40 structures (61 chains) solved
27 are solved in complex with at least one small molecule ligand
2 are solved with an approved drug

EPHB6 is solved in complex with the approved drug(s):

1N1/DASATINIB (2Y6O_A, 6FNM_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


EPHB6 has been screened with 90 compounds (97 bioactivities), 23 compounds have bioactivities that show binding affinity of <= 500nM (25 bioactivities). (see details)