Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

EPHB6 (O15197) - Overview - Molecular Target Synopsis


EPHB6, Ephrin type-B receptor 6
UniProt O15197

Also Known as EPHB6_HUMAN, EPHB6

Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2. Interacts with CBL and EPHB1. Interacts with FYN; this interaction takes place in a ligand-independent manner.

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
1021ENSG00000106123ENST00000392957, ENST00000442129ENSP00000376684, ENSP00000410789O15197-1


EPHB6 is targeted by Approved Drug Vandetanib. (see details)

Sub-cellular localization

UniProt: EPHB6 is active in the following subcellular-locations: membrane, secreted.
GO terms: EPHB6 is active in the following subcellular-locations: cytosol, extracellular region, integral component of plasma membrane, neuron projection, plasma membrane, receptor complex.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project EPHB6 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: CCRF_CEM, COLO205, MOLT_4

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: OCUM-1, JHH-2, COLO 206F

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: K562, SK-N-SH, NHLF

(see details)

3D Structures

At greater than 50% identity similarity to EPHB6 there are:
40 structures (61 chains) solved
27 are solved in complex with at least one small molecule ligand
2 are solved with an approved drug

EPHB6 is solved in complex with the approved drug(s):


(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

EPHB6 has been screened with 90 compounds (97 bioactivities), 23 compounds have bioactivities that show binding affinity of <= 500nM (25 bioactivities). (see details)