Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
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Germline Genetics

MUSK (O15146) - Domains And Structures - Molecular Target Synopsis

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Structural Sequence Similarity Matches
Domains Covered Gene Name (Uniprot) Solved in Complex with Organism PDB Chain Identity E-Value Resolution Ligands Release Date
Protein tyrosine kinase (100%) (view alignment) FGFR4 (P22455) - HUMAN 4UXQ_A 44.22 3.0E-64 1.85Å 0LI 2014-12-03
Protein tyrosine kinase (100%) (view alignment) NTRK3 (Q16288) - HUMAN 3V5Q_B 46.18 3.0E-77 2.19Å 0F4 2012-02-08
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 4F0I_A 49.31 1.0E-80 2.3Å - 2012-09-05
Protein tyrosine kinase (100%) (view alignment) ROR2 (Q01974) - HUMAN 3ZZW_A 42.2 8.0E-70 2.9Å - 2011-09-14
Protein tyrosine kinase (100%) (view alignment) DDR2 (Q16832) - HUMAN 6FER_D 40.72 1.0E-62 2.87Å D6Q 2018-11-28
Protein tyrosine kinase (100%) (view alignment) DDR1 (Q08345) - HUMAN 5BVO_A 40.58 8.0E-62 1.98Å 4VE 2015-08-05
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 6NSP_A 49.31 1.0E-80 2.31Å L0P 2019-05-22
Protein tyrosine kinase (100%) (view alignment) FGFR4 (P22455) - HUMAN 4QRC_A 44.22 3.0E-64 1.9Å 0LI 2014-10-29
Protein tyrosine kinase (100%) (view alignment) RET (P07949) - HUMAN 5FM3_A 40.21 4.0E-62 2.95Å PP1 2016-12-28
Protein tyrosine kinase (99%) (view alignment) IGF1R (P08069) - HUMAN 5HZN_A 43.31 5.0E-69 2.2Å 66A MES 2016-04-06
Protein tyrosine kinase (100%) (view alignment) DDR2 (Q16832) - HUMAN 6FER_I 40.72 1.0E-62 2.87Å D6Q 2018-11-28
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 6D22_A 48.83 1.0E-80 2.458Å - 2018-05-02
Protein tyrosine kinase (100%) (view alignment) DDR1 (Q08345) - HUMAN 5BVW_A 40.58 8.0E-62 1.9Å 1N1 2015-08-05
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 6NSS_A 49.31 2.0E-80 1.97Å L0M 2019-05-22
Protein tyrosine kinase (99%) (view alignment) IGF1R (P08069) - HUMAN 3F5P_L 42.96 3.0E-68 2.9Å 741 2008-12-30
Protein tyrosine kinase (99%) (view alignment) IGF1R (P08069) - HUMAN 5FXR_A 42.96 4.0E-68 2.4Å 8LN 2016-10-19
Protein tyrosine kinase (100%) (view alignment) RET (P07949) - HUMAN 4CKJ_A 40.21 3.0E-62 1.65Å ADN 2014-03-05
Protein tyrosine kinase (100%) (view alignment) INSR (P06213) - HUMAN 3EKK_A 41.87 2.0E-68 2.1Å GS2 2008-12-23
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 4AOJ_B 49.31 1.0E-80 2.75Å V4Z 2012-08-15
Protein tyrosine kinase (100%) (view alignment) DDR1 (Q08345) - HUMAN 6HP9_A 40.58 6.0E-62 1.96Å GKB 2019-01-30
Protein tyrosine kinase (100%) (view alignment) INSR (P06213) Irs2 (P81122) HUMAN 3BU6_A 42.21 7.0E-69 1.95Å - 2008-02-19
Protein tyrosine kinase (99%) (view alignment) IGF1R (P08069) - HUMAN 3F5P_M 42.96 3.0E-68 2.9Å 741 2008-12-30
Protein tyrosine kinase (99%) (view alignment) IGF1R (P08069) - HUMAN 3F5P_G 42.96 3.0E-68 2.9Å 741 2008-12-30
Protein tyrosine kinase (100%) (view alignment) FGFR4 (P22455) - HUMAN 6NVG_A 42.86 9.0E-62 1.99Å XL8 2019-07-10
Protein tyrosine kinase (99%) (view alignment) IGF1R (P08069) - HUMAN 3F5P_B 42.96 3.0E-68 2.9Å 741 2008-12-30
Protein tyrosine kinase (99%) (view alignment) IGF1R (P08069) - HUMAN 3QQU_A 42.96 2.0E-68 2.9Å 01P 2011-04-20
Protein tyrosine kinase (100%) (view alignment) FGFR1 (P11362) - HUMAN 4RWI_A 41.02 2.0E-60 2.29Å - 2015-04-15
Protein tyrosine kinase (100%) (view alignment) - 4CSV_A 42.47 3.0E-61 2.05Å STI 2015-03-04
Protein tyrosine kinase (100%) (view alignment) FGFR4 (P22455) - HUMAN 5NWZ_B 43.88 1.0E-63 2.37Å 9CT 2018-04-04
Protein tyrosine kinase (99%) (view alignment) IGF1R (P08069) - HUMAN 3F5P_E 42.96 3.0E-68 2.9Å 741 2008-12-30
Protein tyrosine kinase (99%) (view alignment) IGF1R (P08069) - HUMAN 1M7N_B 42.96 4.0E-68 2.7Å - 2003-01-07
Protein tyrosine kinase (99%) (view alignment) IGF1R (P08069) - HUMAN 1JQH_C 42.96 3.0E-68 2.1Å ANP 2002-04-19
Protein tyrosine kinase (100%) (view alignment) FGFR4 (P22455) - HUMAN 6NVI_A 42.86 9.0E-62 2.117Å XL7 2019-07-10
Protein tyrosine kinase (99%) (view alignment) IGF1R (P08069) IRS1 (P35568) HUMAN 1K3A_A 42.96 6.0E-68 2.1Å ACP 2001-11-28
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 5KMO_A 49.31 1.0E-80 2.67Å 6UM 2016-12-28
Protein tyrosine kinase (99%) (view alignment) IGF1R (P08069) - HUMAN 3LW0_B 43.31 5.0E-69 1.79Å CCX 2010-09-29
Protein tyrosine kinase (100%) (view alignment) DDR2 (Q16832) - HUMAN 6FER_G 40.72 1.0E-62 2.87Å D6Q 2018-11-28
Protein tyrosine kinase (100%) (view alignment) NTRK3 (Q16288) - HUMAN 4YMJ_B 46.18 4.0E-77 1.92Å 4EJ 2015-06-03
Protein tyrosine kinase (100%) (view alignment) FGFR4 (P22455) - HUMAN 4TYJ_A 43.88 1.0E-63 2.45Å 0LI 2014-09-24
Protein tyrosine kinase (100%) (view alignment) FGFR1 (P11362) - HUMAN 5AM6_B 41.02 3.0E-60 1.96Å 38O 2015-03-18
Protein tyrosine kinase (100%) (view alignment) DDR1 (Q08345) - HUMAN 6FEX_A 41.37 1.0E-63 1.29Å D6Z MES 2018-11-28
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 5KMJ_A 49.31 1.0E-80 2.04Å 6UF 2016-12-28
Protein tyrosine kinase (99%) (view alignment) IGF1R (P08069) - HUMAN 3NW5_A 42.96 2.0E-68 2.14Å LGX 2010-07-28
Protein tyrosine kinase (99%) (view alignment) IGF1R (P08069) - HUMAN 2OJ9_A 42.96 2.0E-68 2Å BMI 2007-05-01
Protein tyrosine kinase (100%) (view alignment) FGFR4 (P22455) - HUMAN 5XFJ_A 44.22 2.0E-64 3.25Å 6LF 2018-08-08
Protein tyrosine kinase (100%) (view alignment) DDR1 (Q08345) - HUMAN 3ZOS_B 40.58 6.0E-62 1.92Å 0LI 2013-05-01
Protein tyrosine kinase (100%) (view alignment) INSR (P06213) (A6XGL2) HUMAN 6PXW_A 41.87 8.0E-68 3.1Å - 2019-09-04
Protein tyrosine kinase (100%) (view alignment) INSR (P06213) - HUMAN 5HHW_A 41.87 2.0E-68 1.79Å 60O 2016-04-13
Protein tyrosine kinase (100%) (view alignment) RET (P07949) - HUMAN 2X2M_B 40.21 3.0E-62 2.5Å X2M 2010-02-09
Protein tyrosine kinase (100%) (view alignment) INSR (P06213) - HUMAN 3EKN_A 41.87 2.0E-68 2.2Å GS3 2008-12-30
Protein tyrosine kinase (100%) (view alignment) FGFR1 (P11362) - HUMAN 2FGI_A 41.02 3.0E-60 2.5Å PD1 1999-09-13
Protein tyrosine kinase (100%) (view alignment) INSR (P06213) Irs2 (P81122) HUMAN 3BU3_A 42.21 7.0E-69 1.65Å - 2008-02-19
Protein tyrosine kinase (100%) (view alignment) FGFR1 (P11362) - HUMAN 5B7V_B 41.02 3.0E-60 2.02Å LWJ 2016-06-22
Protein tyrosine kinase (100%) (view alignment) FGFR1 (P11362) - HUMAN 5B7V_A 41.02 3.0E-60 2.02Å LWJ 2016-06-22
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 5JFV_A 48.83 8.0E-81 1.59Å 6K1 2017-03-01
Protein tyrosine kinase (99%) (view alignment) IGF1R (P08069) - HUMAN 3F5P_R 42.96 3.0E-68 2.9Å 741 2008-12-30
Protein tyrosine kinase (99%) (view alignment) IGF1R (P08069) - HUMAN 5HZN_G 43.31 5.0E-69 2.2Å 66A MES 2016-04-06
Protein tyrosine kinase (100%) (view alignment) NTRK2 (Q16620) - HUMAN 4ASZ_A 48.97 1.0E-81 1.7Å - 2012-08-22
Protein tyrosine kinase (100%) (view alignment) FGFR4 (P22455) - HUMAN 5NUD_A 43.88 1.0E-63 2.5Å 99K 2018-04-04
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 6DKW_A 48.83 8.0E-81 2.91Å GXA 2018-07-11
Protein tyrosine kinase (100%) (view alignment) DDR1 (Q08345) - HUMAN 6FIQ_A 41.37 1.0E-63 1.79Å DJW 2018-11-28
Protein tyrosine kinase (100%) (view alignment) RET (P07949) - HUMAN 2IVS_A 40.21 3.0E-62 2Å ACK 2006-08-14
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 6DKB_A 49.31 2.0E-80 2.68Å FKY 2018-07-11
Protein tyrosine kinase (100%) (view alignment) FGFR4 (P22455) - HUMAN 4R6V_A 43.88 9.0E-64 2.35Å FI3 2014-10-29
Protein tyrosine kinase (100%) (view alignment) DDR2 (Q16832) - HUMAN 6FER_F 40.72 1.0E-62 2.87Å D6Q 2018-11-28
Protein tyrosine kinase (100%) (view alignment) INSR (P06213) - HUMAN 1GAG_A 42.21 4.0E-69 2.7Å - 2001-01-17
Protein tyrosine kinase (100%) (view alignment) FGFR1 (P11362) - HUMAN 5FLF_B 41.02 2.0E-60 2.58Å - 2016-03-30
Protein tyrosine kinase (99%) (view alignment) IGF1R (P08069) - HUMAN 1M7N_A 42.96 4.0E-68 2.7Å - 2003-01-07
Protein tyrosine kinase (100%) (view alignment) RET (P07949) - HUMAN 2IVV_A 39.86 1.0E-61 2.25Å PP1 2006-08-14
Protein tyrosine kinase (100%) (view alignment) RET (P07949) - HUMAN 6NEC_C 40.21 3.0E-62 1.87Å XIN 2019-06-05
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 6PL2_A 49.31 2.0E-80 2.59Å - 2019-09-04
Protein tyrosine kinase (100%) (view alignment) FGFR1 (P11362) - HUMAN 5FLF_D 41.02 2.0E-60 2.58Å PGE 2016-03-30
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 5KMI_A 49.31 1.0E-80 1.868Å 6UE 2016-12-28
Protein tyrosine kinase (99%) (view alignment) IGF1R (P08069) - HUMAN 5HZN_H 43.31 5.0E-69 2.2Å 66A MES 2016-04-06
Protein tyrosine kinase (100%) (view alignment) DDR1 (Q08345) - HUMAN 4BKJ_A 40.58 6.0E-62 1.7Å STI 2013-05-22
Protein tyrosine kinase (100%) (view alignment) FGFR1 (P11362) - HUMAN 4UWY_A 41.02 3.0E-60 2.3Å - 2015-02-25
Protein tyrosine kinase (99%) (view alignment) NTRK1 (P04629) - HUMAN 5KVT_A 50.35 4.0E-80 2.45Å YMX 2017-12-27
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 4AOJ_C 49.31 1.0E-80 2.75Å V4Z 2012-08-15
Immunoglobulin I-set domain (100%) (view alignment) Musk (Q62838) - NORWAY RAT 2IEP_B 98.95 2.0E-108 2.205Å - 2006-11-28
Protein tyrosine kinase (99%) (view alignment) IGF1R (P08069) - HUMAN 2ZM3_D 42.96 3.0E-68 2.27Å 575 2008-06-10
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 4AOJ_A 49.31 1.0E-80 2.75Å V4Z 2012-08-15
Protein tyrosine kinase (100%) (view alignment) RET (P07949) - HUMAN 4CKI_A 39.86 1.0E-61 2.11Å ADN 2014-03-05
Protein tyrosine kinase (99%) (view alignment) IGF1R (P08069) - HUMAN 1P4O_A 43.31 7.0E-69 1.5Å - 2003-04-29
Protein tyrosine kinase (100%) (view alignment) DDR1 (Q08345) - HUMAN 6BSD_A 40.58 4.0E-61 2.606Å 1N1 2018-12-05
Protein tyrosine kinase (99%) (view alignment) IGF1R (P08069) - HUMAN 3LVP_A 42.96 4.0E-68 3Å EPE PDR 2010-07-21
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 6NPT_A 49.31 2.0E-80 2.19Å KWY 2019-05-22
Protein tyrosine kinase (100%) (view alignment) FGFR4 (P22455) - HUMAN 6NVH_A 42.86 9.0E-62 1.9Å XL6 2019-07-10
Protein tyrosine kinase (100%) (view alignment) DDR2 (Q16832) - HUMAN 6FER_H 40.72 1.0E-62 2.87Å D6Q 2018-11-28
Protein tyrosine kinase (100%) (view alignment) DDR2 (Q16832) - HUMAN 6FER_B 40.72 1.0E-62 2.87Å D6Q 2018-11-28
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 6D1Z_A 49.31 2.0E-80 1.87Å FQD FQM 2018-05-02
Protein tyrosine kinase (99%) (view alignment) IGF1R (P08069) - HUMAN 2ZM3_A 42.96 3.0E-68 2.27Å 575 2008-06-10
Protein tyrosine kinase (100%) (view alignment) INSR (P06213) - HUMAN 1IRK_A 42.21 4.0E-69 2.1Å - 1995-02-27
Protein tyrosine kinase (100%) (view alignment) INSR (P06213) Irs2 (P81122) HUMAN 3BU5_A 42.21 7.0E-69 2.1Å ATP 2008-02-19
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 5KMN_A 49.31 1.0E-80 2.136Å 6UK 2016-12-28
Protein tyrosine kinase (99%) (view alignment) IGF1R (P08069) - HUMAN 1JQH_A 42.96 3.0E-68 2.1Å ANP 2002-04-19
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 4GT5_A 49.31 2.0E-80 2.398Å - 2012-09-26
Protein tyrosine kinase (100%) (view alignment) DDR2 (Q16832) - HUMAN 6FER_K 40.72 1.0E-62 2.87Å D6Q 2018-11-28
Protein tyrosine kinase (100%) (view alignment) DDR1 (Q08345) - HUMAN 6BRJ_A 40.58 4.0E-61 2.23Å VX6 2018-12-05
Protein tyrosine kinase (99%) (view alignment) IGF1R (P08069) - HUMAN 3F5P_T 42.96 3.0E-68 2.9Å 741 2008-12-30
Protein tyrosine kinase (100%) (view alignment) DDR2 (Q16832) - HUMAN 6FER_C 40.72 1.0E-62 2.87Å D6Q 2018-11-28
Protein tyrosine kinase (100%) (view alignment) INSR (P06213) PTPN1 (P18031) HUMAN 2B4S_D 42.21 7.0E-69 2.3Å - 2005-11-15
Protein tyrosine kinase (100%) (view alignment) RET (P07949) - HUMAN 6FEK_A 40.27 6.0E-62 2.08Å ADN 2018-02-28
Protein tyrosine kinase (100%) (view alignment) INSR (P06213) - HUMAN 5E1S_A 41.87 2.0E-68 2.26Å 5JA 2015-10-14
Protein tyrosine kinase (99%) (view alignment) IGF1R (P08069) - HUMAN 5HZN_F 43.31 5.0E-69 2.2Å 66A MES 2016-04-06
Fz domain (100%) (view alignment) Musk (Q62838) - RAT 3HKL_A 82.7 2.0E-86 2.1Å NAG 2009-08-25
Protein tyrosine kinase (99%) (view alignment) IGF1R (P08069) - HUMAN 3F5P_D 42.96 3.0E-68 2.9Å 741 2008-12-30
Protein tyrosine kinase (100%) (view alignment) DDR1 (Q08345) - HUMAN 6HP9_B 40.58 6.0E-62 1.96Å GKB 2019-01-30
Protein tyrosine kinase (100%) (view alignment) DDR1 (Q08345) - HUMAN 6GWR_B 40.58 6.0E-62 2.07Å FEW 2018-08-08
Protein tyrosine kinase (100%) (view alignment) FGFR4 (P22455) - HUMAN 4XCU_A 42.86 9.0E-62 1.71Å 40M 2015-04-01
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 4PMT_A 49.31 1.0E-80 2.1Å 31Y 2014-06-18
Protein tyrosine kinase (100%) (view alignment) FGFR1 (P11362) - HUMAN 1FGK_B 41.02 3.0E-60 2Å - 1997-07-23
Protein tyrosine kinase (100%) (view alignment) RET (P07949) - HUMAN 6NE7_A 39.86 2.0E-61 1.99Å AMP 2019-06-05
Protein tyrosine kinase (100%) (view alignment) ROR2 (Q01974) - HUMAN 4GT4_B 41.84 2.0E-70 2.399Å - 2012-09-26
Protein tyrosine kinase (100%) (view alignment) FGFR1 (P11362) - HUMAN 5AM7_B 41.02 2.0E-60 1.957Å 38O 2015-03-18
Protein tyrosine kinase (99%) (view alignment) IGF1R (P08069) - HUMAN 3F5P_I 42.96 3.0E-68 2.9Å 741 2008-12-30
Protein tyrosine kinase (99%) (view alignment) IGF1R (P08069) - HUMAN 3LW0_D 43.31 5.0E-69 1.79Å CCX 2010-09-29
Protein tyrosine kinase (99%) (view alignment) IGF1R (P08069) - HUMAN 3QQU_C 42.96 2.0E-68 2.9Å 01P 2011-04-20
Protein tyrosine kinase (99%) (view alignment) IGF1R (P08069) - HUMAN 3NW7_A 42.96 2.0E-68 2.11Å LGV 2010-07-28
Protein tyrosine kinase (100%) (view alignment) RET (P07949) - HUMAN 5FM2_A 40.21 4.0E-62 3.3Å PP1 2016-12-28
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 4PMM_A 49.31 1.0E-80 2Å 31V 2014-06-18
Protein tyrosine kinase (100%) (view alignment) DDR2 (Q16832) - HUMAN 6FER_J 40.72 1.0E-62 2.87Å D6Q 2018-11-28
Protein tyrosine kinase (99%) (view alignment) IGF1R (P08069) - HUMAN 5FXS_A 42.61 2.0E-67 1.9Å OZN 2016-10-19
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 4YPS_A 49.31 1.0E-80 2.1Å 4F6 2015-06-03
Protein tyrosine kinase (99%) (view alignment) IGF1R (P08069) - HUMAN 3LVP_D 42.96 4.0E-68 3Å PDR 2010-07-21
Protein tyrosine kinase (100%) (view alignment) INSR (P06213) - HUMAN 3ETA_A 42.21 2.0E-69 2.6Å 351 2009-05-26
Protein tyrosine kinase (100%) (view alignment) INSR (P06213) - HUMAN 1I44_A 41.87 3.0E-68 2.4Å ACP 2001-03-07
Protein tyrosine kinase (100%) (view alignment) FGFR4 (P22455) - HUMAN 4QQT_A 44.22 3.0E-64 1.5Å - 2014-10-29
Protein tyrosine kinase (100%) (view alignment) DDR2 (Q16832) - HUMAN 6FER_E 40.72 1.0E-62 2.87Å D6Q 2018-11-28
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 5H3Q_A 49.31 1.0E-80 2.1Å 7HF 2017-02-22
Protein tyrosine kinase (100%) (view alignment) RET (P07949) - HUMAN 2X2L_A 40.21 3.0E-62 2Å X2L 2010-02-09
Protein tyrosine kinase (99%) (view alignment) IGF1R (P08069) - HUMAN 3I81_A 42.96 2.0E-68 2.08Å EBI 2009-12-22
Protein tyrosine kinase (99%) (view alignment) IGF1R (P08069) - HUMAN 1JQH_B 42.96 3.0E-68 2.1Å ANP 2002-04-19
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 4F0I_B 49.31 1.0E-80 2.3Å - 2012-09-05
Protein tyrosine kinase (100%) (view alignment) NTRK3 (Q16288) - HUMAN 3V5Q_A 46.18 3.0E-77 2.19Å 0F4 2012-02-08
Protein tyrosine kinase (100%) (view alignment) INSR (P06213) - HUMAN 4IBM_A 42.21 9.0E-69 1.8Å IR1 2013-08-21
Protein tyrosine kinase (99%) (view alignment) IGF1R (P08069) - HUMAN 3LW0_A 43.31 5.0E-69 1.79Å CCX 2010-09-29
Protein tyrosine kinase (100%) (view alignment) NTRK3 (Q16288) - HUMAN 4YMJ_A 46.18 4.0E-77 1.92Å 4EJ 2015-06-03
Protein tyrosine kinase (100%) (view alignment) FGFR1 (P11362) - HUMAN 2FGI_B 41.02 3.0E-60 2.5Å PD1 1999-09-13
Protein tyrosine kinase (100%) (view alignment) FGFR1 (P11362) - HUMAN 4RWI_B 41.02 2.0E-60 2.29Å - 2015-04-15
Protein tyrosine kinase (100%) (view alignment) RET (P07949) - HUMAN 2IVU_A 40.21 3.0E-62 2.5Å ZD6 2006-08-10
Protein tyrosine kinase (100%) (view alignment) FGFR4 (P22455) - HUMAN 6JPJ_A 44.22 3.0E-64 2.638Å FGF 2019-05-15
Protein tyrosine kinase (100%) (view alignment) DDR1 (Q08345) - HUMAN 4CKR_A 40.58 6.0E-62 2.2Å DI1 2014-01-15
Protein tyrosine kinase (100%) (view alignment) INSR (P06213) Sh2b2 (Q9Z200) HUMAN 1RQQ_A 42.21 7.0E-69 2.6Å - 2003-12-30
Protein tyrosine kinase (100%) (view alignment) FGFR4 (P22455) - HUMAN 5NUD_B 43.88 1.0E-63 2.5Å 99K 2018-04-04
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 4PMP_A 49.31 1.0E-80 1.8Å 31W 2014-06-18
Protein tyrosine kinase (100%) (view alignment) FGFR4 (P22455) - HUMAN 4TYI_A 43.88 1.0E-63 3.4Å 38O 2014-09-24
Protein tyrosine kinase (100%) (view alignment) FGFR1 (P11362) - HUMAN 4RWK_A 41.02 2.0E-60 2.98Å 66T 2015-04-15
Protein tyrosine kinase (100%) (view alignment) DDR1 (Q08345) - HUMAN 6FIO_A 41.37 1.0E-63 1.99Å DJH 2018-11-28
Protein tyrosine kinase (99%) (view alignment) IGF1R (P08069) - HUMAN 4D2R_A 42.96 2.0E-68 2.1Å DYK 2015-04-22
Protein tyrosine kinase (99%) (view alignment) IGF1R (P08069) - HUMAN 5HZN_D 43.31 5.0E-69 2.2Å 66A MES 2016-04-06
Protein tyrosine kinase (100%) (view alignment) FGFR4 (P22455) - HUMAN 4QQC_A 43.88 1.0E-63 2.35Å 37O 2014-10-29
Protein tyrosine kinase (100%) (view alignment) FGFR4 (P22455) - HUMAN 4TYE_A 43.88 1.0E-63 2.8Å - 2014-09-24
Protein tyrosine kinase (100%) (view alignment) FGFR1 (P11362) - HUMAN 5FLF_E 41.02 2.0E-60 2.58Å - 2016-03-30
Protein tyrosine kinase (99%) (view alignment) IGF1R (P08069) - HUMAN 3F5P_K 42.96 3.0E-68 2.9Å 741 2008-12-30
Protein tyrosine kinase (100%) (view alignment) INSR (P06213) - HUMAN 3ETA_B 42.21 2.0E-69 2.6Å 351 2009-05-26
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 5KMK_A 49.31 1.0E-80 2.24Å 6UG 2016-12-28
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 4YNE_A 49.31 1.0E-80 2.02Å 4EK 2015-06-03
Protein tyrosine kinase (100%) (view alignment) ROR2 (Q01974) - HUMAN 3ZZW_B 42.2 8.0E-70 2.9Å - 2011-09-14
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 6DKG_A 49.31 2.0E-80 2.53Å 22L GO7 2018-07-11
Protein tyrosine kinase (100%) (view alignment) INSR (P06213) - HUMAN 4IBM_B 42.21 9.0E-69 1.8Å IR1 2013-08-21
Protein tyrosine kinase (99%) (view alignment) IGF1R (P08069) - HUMAN 3F5P_H 42.96 3.0E-68 2.9Å 741 2008-12-30
Protein tyrosine kinase (100%) (view alignment) DDR2 (Q16832) - HUMAN 6FER_L 40.72 1.0E-62 2.87Å D6Q 2018-11-28
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 5JFW_A 48.83 8.0E-81 1.52Å 6K2 2017-03-01
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 6D1Y_A 49.31 2.0E-80 1.93Å FQJ 2018-05-02
Protein tyrosine kinase (100%) (view alignment) INSR (P06213) - HUMAN 1IR3_A 42.21 4.0E-69 1.9Å ANP 1998-01-07
Protein tyrosine kinase (99%) (view alignment) IGF1R (P08069) - HUMAN 3F5P_F 42.96 3.0E-68 2.9Å 741 2008-12-30
Protein tyrosine kinase (100%) (view alignment) INSR (P06213) IRS1 (P35568) HUMAN 2Z8C_A 42.21 4.0E-69 3.25Å S91 2008-08-12
Protein tyrosine kinase (100%) (view alignment) NTRK2 (Q16620) - HUMAN 4AT5_A 48.97 1.0E-81 1.71Å MUJ 2012-08-22
Protein tyrosine kinase (100%) (view alignment) FGFR4 (P22455) - HUMAN 5JKG_A 44.22 3.0E-64 2.35Å 6LF 2016-10-05
Protein tyrosine kinase (100%) (view alignment) FGFR4 (P22455) - HUMAN 4QQ5_A 43.88 9.0E-64 2.2Å 37O 2014-10-29
Protein tyrosine kinase (100%) (view alignment) NTRK2 (Q16620) - HUMAN 4AT4_A 48.97 1.0E-81 2.36Å T6E 2012-08-22
Protein tyrosine kinase (100%) (view alignment) INSR (P06213) - HUMAN 1P14_A 41.87 3.0E-68 1.9Å - 2003-07-22
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 6DKI_A 49.31 2.0E-80 2.11Å GOD 22L 2018-07-11
Protein tyrosine kinase (100%) (view alignment) DDR2 (Q16832) - HUMAN 6FER_A 40.72 1.0E-62 2.87Å D6Q 2018-11-28
Protein tyrosine kinase (100%) (view alignment) RET (P07949) - HUMAN 2X2M_A 40.21 3.0E-62 2.5Å X2M 2010-02-09
Protein tyrosine kinase (100%) (view alignment) INSR (P06213) (A6XGL2) HUMAN 6PXV_A 41.87 8.0E-68 3.2Å - 2019-09-04
Protein tyrosine kinase (100%) (view alignment) DDR1 (Q08345) - HUMAN 3ZOS_A 40.58 6.0E-62 1.92Å 0LI 2013-05-01
Protein tyrosine kinase (99%) (view alignment) IGF1R (P08069) - HUMAN 5HZN_B 43.31 5.0E-69 2.2Å 66A MES 2016-04-06
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 5JFX_A 48.83 8.0E-81 1.63Å 6K4 2017-03-01
Protein tyrosine kinase (100%) (view alignment) RET (P07949) - HUMAN 6NJA_A 40.21 3.0E-62 1.92Å ADE 2019-06-05
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 5JFS_A 48.83 8.0E-81 1.66Å 6K0 2017-03-01
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 5WR7_A 49.31 2.0E-80 2.76Å RCH 2017-12-06
Protein tyrosine kinase (100%) (view alignment) RET (P07949) - HUMAN 2IVT_A 40.21 3.0E-62 2.6Å AMP 2006-08-14
Protein tyrosine kinase (100%) (view alignment) FGFR4 (P22455) - HUMAN 5NWZ_A 43.88 1.0E-63 2.37Å 9CT 2018-04-04
Protein tyrosine kinase (100%) (view alignment) FGFR4 (P22455) - HUMAN 4TYG_A 43.88 1.0E-63 2.4Å - 2014-09-24
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 4PMS_A 49.31 1.0E-80 2.8Å 31X 2014-06-18
Protein tyrosine kinase (100%) (view alignment) INSR (P06213) - HUMAN 4XLV_A 42.21 1.0E-68 2.3Å ACP 2015-03-25
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 6J5L_A 49.31 1.0E-80 2.3Å B9C 2019-07-17
Protein tyrosine kinase (100%) (view alignment) FGFR4 (P22455) - HUMAN 4QQJ_A 44.22 2.0E-64 1.68Å - 2014-10-29
Protein tyrosine kinase (100%) (view alignment) INSR (P06213) PTPN1 (P18031) HUMAN 2B4S_B 42.21 7.0E-69 2.3Å - 2005-11-15
Protein tyrosine kinase (100%) (view alignment) INSR (P06213) GRB14 (Q14449) HUMAN 2AUH_A 42.21 7.0E-69 3.2Å - 2005-11-01
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 5KMM_A 49.31 1.0E-80 2.117Å 6UJ 2016-12-28
Protein tyrosine kinase (99%) (view alignment) IGF1R (P08069) - HUMAN 3F5P_S 42.96 3.0E-68 2.9Å 741 2008-12-30
Protein tyrosine kinase (100%) (view alignment) DDR1 (Q08345) - HUMAN 5BVK_A 40.58 8.0E-62 2.27Å 4VC 2015-08-05
Protein tyrosine kinase (99%) (view alignment) IGF1R (P08069) - HUMAN 2ZM3_B 42.96 3.0E-68 2.27Å 575 2008-06-10
Protein tyrosine kinase (99%) (view alignment) IGF1R (P08069) - HUMAN 3O23_A 42.96 2.0E-68 2.1Å MQY 2011-05-04
Protein tyrosine kinase (100%) (view alignment) DDR1 (Q08345) - HUMAN 5FDX_A 39.58 5.0E-62 2.65Å 5X1 2016-10-26
Protein tyrosine kinase (100%) (view alignment) DDR1 (Q08345) - HUMAN 6FIL_A 41.37 1.0E-63 1.73Å D6W 2018-11-28
Protein tyrosine kinase (99%) (view alignment) IGF1R (P08069) - HUMAN 3LVP_C 42.96 4.0E-68 3Å PDR 2010-07-21
Protein tyrosine kinase (100%) (view alignment) FGFR4 (P22455) - HUMAN 6NVK_A 42.86 9.0E-62 2.3Å XL9 2019-07-10
Protein tyrosine kinase (100%) (view alignment) FGFR3 (P22607) - HUMAN 4K33_A 41.36 5.0E-61 2.34Å ACP 2013-09-11
Protein tyrosine kinase (100%) (view alignment) FGFR1 (P11362) - HUMAN 5AM6_A 41.02 3.0E-60 1.96Å 38O 2015-03-18
Protein tyrosine kinase (100%) (view alignment) DDR1 (Q08345) - HUMAN 6GWR_A 40.58 6.0E-62 2.07Å FEW 2018-08-08
Protein tyrosine kinase (99%) (view alignment) IGF1R (P08069) - HUMAN 3NW6_A 42.96 2.0E-68 2.2Å LGW 2010-07-28
Protein tyrosine kinase (100%) (view alignment) DDR1 (Q08345) - HUMAN 6FIN_A 41.37 1.0E-63 1.67Å DJQ 2018-11-28
Protein tyrosine kinase (100%) (view alignment) RET (P07949) - HUMAN 6NEC_A 40.21 3.0E-62 1.87Å XIN 2019-06-05
Protein tyrosine kinase (100%) (view alignment) NTRK2 (Q16620) - HUMAN 4AT3_A 48.97 1.0E-81 1.77Å LTI 2012-08-22
Protein tyrosine kinase (100%) (view alignment) DDR1 (Q08345) - HUMAN 5FDX_B 39.58 5.0E-62 2.65Å 5X1 2016-10-26
Protein tyrosine kinase (100%) (view alignment) DDR1 (Q08345) - HUMAN 4BKJ_B 40.58 6.0E-62 1.7Å STI 2013-05-22
Protein tyrosine kinase (100%) (view alignment) FGFR1 (P11362) - HUMAN 5FLF_C 41.02 2.0E-60 2.58Å PGE 2016-03-30
Protein tyrosine kinase (100%) (view alignment) FGFR1 (P11362) - HUMAN 1FGI_B 41.02 3.0E-60 2.5Å SU1 1998-04-08
Protein tyrosine kinase (100%) (view alignment) FGFR1 (P11362) - HUMAN 4UWY_B 41.02 3.0E-60 2.3Å - 2015-02-25
Protein tyrosine kinase (100%) (view alignment) INSR (P06213) Sh2b2 (Q9Z200) HUMAN 1RQQ_B 42.21 7.0E-69 2.6Å - 2003-12-30
Protein tyrosine kinase (99%) (view alignment) IGF1R (P08069) - HUMAN 3D94_A 42.96 7.0E-68 2.3Å D94 2008-07-29
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 5KML_A 49.31 1.0E-80 2.01Å 6UH 2016-12-28
Protein tyrosine kinase (99%) (view alignment) IGF1R (P08069) - HUMAN 5FXQ_A 42.96 3.0E-68 2.3Å GD5 2016-10-19
Protein tyrosine kinase (99%) (view alignment) IGF1R (P08069) - HUMAN 5HZN_C 43.31 5.0E-69 2.2Å 66A MES 2016-04-06
Protein tyrosine kinase (99%) (view alignment) IGF1R (P08069) - HUMAN 3LW0_C 43.31 5.0E-69 1.79Å CCX 2010-09-29
Protein tyrosine kinase (99%) (view alignment) IGF1R (P08069) - HUMAN 5HZN_E 43.31 5.0E-69 2.2Å 66A MES 2016-04-06
Protein tyrosine kinase (99%) (view alignment) IGF1R (P08069) - HUMAN 3QQU_B 42.96 2.0E-68 2.9Å 01P 2011-04-20
Protein tyrosine kinase (100%) (view alignment) FGFR1 (P11362) - HUMAN 4RWK_B 41.02 2.0E-60 2.98Å 66T 2015-04-15
Protein tyrosine kinase (100%) (view alignment) DDR1 (Q08345) - HUMAN 5BVN_A 40.58 8.0E-62 2.2Å 4VD 2015-08-12
Protein tyrosine kinase (100%) (view alignment) RET (P07949) - HUMAN 2X2K_A 40.21 3.0E-62 2.6Å X2K 2010-02-09
Protein tyrosine kinase (99%) (view alignment) IGF1R (P08069) - HUMAN 3F5P_A 42.96 3.0E-68 2.9Å 741 2008-12-30
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 6D20_A 49.31 2.0E-80 1.94Å FQG FQD 2018-05-02
Protein tyrosine kinase (100%) (view alignment) FGFR1 (P11362) - HUMAN 1FGK_A 41.02 3.0E-60 2Å - 1997-07-23
Protein tyrosine kinase (100%) (view alignment) ROR2 (Q01974) - HUMAN 4GT4_A 41.84 2.0E-70 2.399Å - 2012-09-26
Protein tyrosine kinase (99%) (view alignment) IGF1R (P08069) - HUMAN 1P4O_B 43.31 7.0E-69 1.5Å - 2003-04-29
Protein tyrosine kinase (100%) (view alignment) INSR (P06213) (A6XGL2) HUMAN 6PXV_C 41.87 8.0E-68 3.2Å - 2019-09-04
Protein tyrosine kinase (100%) (view alignment) Musk (Q62838) - NORWAY RAT 1LUF_A 97.35 0 2.05Å - 2002-09-11
Immunoglobulin I-set domain (100%) (view alignment) Musk (Q62838) - NORWAY RAT 2IEP_A 98.95 2.0E-108 2.205Å - 2006-11-28
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 6PL3_A 49.31 2.0E-80 3Å - 2019-09-04
Protein tyrosine kinase (100%) (view alignment) NTRK1 (P04629) - HUMAN 6DKW_B 48.83 8.0E-81 2.91Å GXA 2018-07-11
Protein tyrosine kinase (100%) (view alignment) DDR1 (Q08345) - HUMAN 6FEW_A 41.37 1.0E-63 1.44Å D6W 2018-11-28
Protein tyrosine kinase (100%) (view alignment) RET (P07949) - HUMAN 2IVS_B 40.21 3.0E-62 2Å ACK 2006-08-14
Protein tyrosine kinase (100%) (view alignment) FGFR4 (P22455) - HUMAN 5XFF_A 44.22 2.0E-64 2.7Å 6LF 2018-09-05
Protein tyrosine kinase (100%) (view alignment) INSR (P06213) (A6XGL2) HUMAN 6PXW_B 41.87 8.0E-68 3.1Å - 2019-09-04
Protein tyrosine kinase (100%) (view alignment) FGFR1 (P11362) - HUMAN 5FLF_A 41.02 2.0E-60 2.58Å - 2016-03-30
Protein tyrosine kinase (99%) (view alignment) IGF1R (P08069) - HUMAN 3LVP_B 42.96 4.0E-68 3Å PDR 2010-07-21
Protein tyrosine kinase (100%) (view alignment) FGFR1 (P11362) - HUMAN 5AM7_A 41.02 2.0E-60 1.957Å 38O 2015-03-18
Protein tyrosine kinase (100%) (view alignment) RET (P07949) - HUMAN 5AMN_A 40.21 3.0E-61 2.57Å DTQ 2016-02-17
Fz domain (100%) (view alignment) Musk (Q62838) - RAT 3HKL_B 82.7 2.0E-86 2.1Å NAG 2009-08-25
Protein tyrosine kinase (100%) (view alignment) DDR1 (Q08345) - HUMAN 5FDP_A 39.58 5.0E-62 2.25Å 5WR 2016-06-08
Protein tyrosine kinase (99%) (view alignment) IGF1R (P08069) - HUMAN 3F5P_J 42.96 3.0E-68 2.9Å 741 2008-12-30
Protein tyrosine kinase (99%) (view alignment) IGF1R (P08069) - HUMAN 2ZM3_C 42.96 3.0E-68 2.27Å 575 2008-06-10
Protein tyrosine kinase (99%) (view alignment) IGF1R (P08069) - HUMAN 3F5P_C 42.96 3.0E-68 2.9Å 741 2008-12-30
Protein tyrosine kinase (99%) (view alignment) NTRK1 (P04629) - HUMAN 5I8A_A 50.35 3.0E-80 2.33Å 69C 2017-08-09
Protein tyrosine kinase (100%) (view alignment) - 4UEU_A 42.47 3.0E-61 2.95Å ACP 2015-02-18
Protein tyrosine kinase (99%) (view alignment) IGF1R (P08069) - HUMAN 3QQU_D 42.96 2.0E-68 2.9Å 01P 2011-04-20
Protein tyrosine kinase (100%) (view alignment) FGFR4 (P22455) - HUMAN 6NVJ_A 42.86 9.0E-62 2.3Å XL5 2019-07-10