ARPC2 (O15144) - Overview - Molecular Target Synopsis
ARPC2, Actin-related protein 2/3 complex subunit 2
Also Known as ARPC2_HUMAN, ARPC2, ARC34
Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). Seems to contact the mother actin filament (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). Component of the Arp2/3 complex composed of ACTR2/ARP2, ACTR3/ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC (PubMed:9230079, PubMed:11741539). Interacts with SHANK3; the interaction probably mediates the association of SHANK3 with the Arp2/3 complex.
|Protein Length||Ensembl Gene||Ensembl Transcript||Ensembl Protein||Uniprot Isoform|
|300||ENSG00000163466||ENST00000315717, ENST00000295685||ENSP00000327137, ENSP00000295685||O15144-1, Q5R5Z5-1|
UniProt: ARPC2 is active in the following subcellular-locations: cell junction, cell projection, cytoplasm, cytoskeleton, nucleus, synapse, synaptosome.
GO terms: ARPC2 is active in the following subcellular-locations: actin cytoskeleton, Arp2/3 protein complex, cytosol, endosome, extracellular exosome, focal adhesion, glutamatergic synapse, lamellipodium, muscle cell projection membrane, neuron projection, nucleus, site of double-strand break.