Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

ARPC2 (O15144) - Overview - Molecular Target Synopsis


ARPC2, Actin-related protein 2/3 complex subunit 2
UniProt O15144

Also Known as ARPC2_HUMAN, ARPC2, ARC34

Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). Seems to contact the mother actin filament (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). Component of the Arp2/3 complex composed of ACTR2/ARP2, ACTR3/ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC (PubMed:9230079, PubMed:11741539). Interacts with SHANK3; the interaction probably mediates the association of SHANK3 with the Arp2/3 complex (By similarity).

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

UniProt: ARPC2 is active in the following subcellular-locations: cell junction, cell projection, cytoplasm, cytoskeleton, nucleus, synapse, synaptosome.
GO terms: ARPC2 is active in the following subcellular-locations: actin cytoskeleton, Arp2/3 protein complex, cytosol, endosome, extracellular exosome, focal adhesion, glutamatergic synapse, lamellipodium, muscle cell projection membrane, neuron projection, nucleus, site of double-strand break.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project ARPC2 has gain in 0 cell-lines, loss in 1 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: TK_10, HS578T, HL_60

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: OCI-LY-3, HCC461, RT4

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HSMM, HMEC

(see details)

3D Structures

At greater than 90% identity similarity to ARPC2 there are:
20 structures (22 chains) solved
0 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis