Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ARPC2 (O15144) - Overview - Molecular Target Synopsis

Protein


ARPC2, Actin-related protein 2/3 complex subunit 2
UniProt O15144

Also Known as ARPC2_HUMAN, ARPC2, ARC34

Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). Seems to contact the mother actin filament (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). Component of the Arp2/3 complex composed of ACTR2/ARP2, ACTR3/ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC (PubMed:9230079, PubMed:11741539). Interacts with SHANK3; the interaction probably mediates the association of SHANK3 with the Arp2/3 complex.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ARPC2 is active in the following subcellular-locations: cell junction, cell projection, cytoplasm, cytoskeleton, nucleus, synapse, synaptosome.
GO terms: ARPC2 is active in the following subcellular-locations: actin cytoskeleton, Arp2/3 protein complex, cytosol, endosome, extracellular exosome, focal adhesion, glutamatergic synapse, lamellipodium, muscle cell projection membrane, neuron projection, nucleus, site of double-strand break.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ARPC2 has gain in 0 cell-lines, loss in 1 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: TK_10, HS578T, HL_60

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: OCI-LY-3, HCC461, RT4

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HSMM, HMEC

(see details)

3D Structures


At greater than 90% identity similarity to ARPC2 there are:
20 structures (22 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis