Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

DEGS1 (O15121) - Overview - Molecular Target Synopsis

Protein


DEGS1, Sphingolipid delta(4)-desaturase DES1
Enzyme Classification 1.14.19.17
UniProt O15121

Also Known as DEGS1_HUMAN, DEGS1, DES1, MLD

Has sphingolipid-delta-4-desaturase activity. Converts D-erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine).

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
323ENSG00000143753ENST00000391877, ENST00000323699ENSP00000375749, ENSP00000316476O15121-1
267ENSG00000143753ENST00000415210ENSP00000400545

Sub-cellular localization


UniProt: DEGS1 is active in the following subcellular-locations: endoplasmic reticulum membrane, membrane, mitochondrion.
GO terms: DEGS1 is active in the following subcellular-locations: endoplasmic reticulum, endoplasmic reticulum membrane, integral component of plasma membrane, membrane, mitochondrion, plasma membrane, specific granule membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project DEGS1 has gain in 1 cell-lines, loss in 0 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HS578T, OVCAR_4, SR

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H1568, HCC2218, YMB-1-E

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HSMM, IMR-90

(see details)


Screening and Chemistry


DEGS1 has been screened with 12 compounds (18 bioactivities). (see details)