Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

DCLK1 (O15075) - Overview - Molecular Target Synopsis

Protein


DCLK1, Serine/threonine-protein kinase DCLK1
Enzyme Classification 2.7.11.1
UniProt O15075

Also Known as DCLK1_HUMAN, DCLK1, DCAMKL1, DCDC3A, KIAA0369

Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system.

5JZJ
CRYSTAL STRUCTURE OF DCLK1-KD IN COMPLEX WITH AMPPN
RCSB/PDB
Inspect Structure
See all 3D Structures for DCLK1

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


GO terms: DCLK1 is active in the following subcellular-locations: integral component of plasma membrane, postsynaptic density.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project DCLK1 has gain in 2 cell-lines, loss in 4 cell-lines and no signal in 999 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: RXF_393, UACC_257, A498

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H1930, SW 1573, NCI-H1915

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HSMM, SK-N-SH, NHLF

(see details)

RNA Interference


DCLK1 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: CAL120, MDAMB134VI. (see details)

3D Structures


For DCLK1 there are:
5 structures (7 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


DCLK1 has been screened with 116 compounds (155 bioactivities), 7 compounds have bioactivities that show binding affinity of <= 500nM (10 bioactivities). (see details)