Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RIMBP2 (O15034) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 02/07/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 02/07/2019)


Chains assessed3
Chains with at least one site assessed as druggable using the strict criteria0
Chains with at least one site assessed as druggable using the relaxed criteria1


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
2CSP_A RIMS-binding protein 2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.09 51.5 16.9 No No
2 empty 2.33 50.7 14 No No
3 empty 1.98 61.3 13.7 No No
4 empty 2.4 54 18.6 No No
5 empty 3.04 59.5 11.5 No No
6 empty 1.89 57.3 13.8 No No
7 empty 1.61 71.8 8.7 No No
8 empty 2.21 66 11.6 No No
9 empty 2.48 59.9 11 No No
10 empty 2.29 67.6 9.1 No No
1WIE_A RIMS-binding protein 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.57 59.4 34 Yes No
2 empty 2.49 61.6 23.4 No No
3 empty 2.55 57.8 13.8 No No
4 empty 2.22 53.1 7.7 No No
5 empty 3.17 69.8 6.4 No No
6 empty 2.7 61.5 7.7 No No
7 empty 3.3 62.2 8 No No
8 empty 2.72 46 8.2 No No
9 empty 2.56 45.6 6.3 No No
2CSI_A RIMS-binding protein 2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.7 55.4 21.8 No No
2 empty 2.77 68 16.7 No No
3 empty 2.05 64.9 19.1 No No
4 empty 2.15 65.9 8.5 No No
5 empty 2.92 60.9 9.8 No No
6 empty 2.53 61.3 8.7 No No
7 empty 1.99 56.6 9 No No
8 empty 3.09 50.4 6.5 No No
9 empty 2.71 52.6 7.9 No No
10 empty 2.64 74.7 0 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed4
Domains assessed as druggable using the strict criteria0
Domains assessed as druggable using the relaxed criteria2

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
1WIE_A (114668) RIMS-binding protein 2 SH3-like barrel, SH3-domain, SH3-domain Yes No
2CSI_A (3060356) RIMS-binding protein 2 SH3-like barrel, SH3-domain, UNMATCHED No No
2CSP_A (130779) RIMS-binding protein 2 Immunoglobulin-like beta-sandwich, Fibronectin type III, Fibronectin type III No No
2CSQ_A (3060358) RIMS-binding protein 2 SH3-like barrel, SH3-domain, UNMATCHED Yes No
Ligand-based Druggability Score: -0.3
Ligand-based Druggability Score Percentile: 76%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


RIMBP2 is involved in 2 interactions in the network.


Druggability
Overall Druggability Percentile: 20.72
Druggability for Cancer Therapeutics: 11.60
Druggability for Other Therapeutics: 5.89
Cancer-Associated
Cancer-associated percentile : 30.00
Network Articulation Point
Is RIMBP2 critical for communication in the network?


Detailed Graph Legend:Help