Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RIMBP2 (O15034) - Overview - Molecular Target Synopsis

Protein


RIMBP2, RIMS-binding protein 2
UniProt O15034

Also Known as RIMB2_HUMAN, RIMBP2, KIAA0318, RBP2

Plays a role in the synaptic transmission as bifunctional linker that interacts simultaneously with RIMS1, RIMS2, CACNA1D and CACNA1B. Interacts with RIMS1, RIMS2, CACNA1D and CACNA1B, and potentially with other Ca(2+) channel alpha-1 isoforms.

2CSP
SOLUTION STRUCTURE OF THE FNIII DOMAIN OF HUMAN RIM-BINDING PROTEIN 2
RCSB/PDB
Inspect Structure
See all 3D Structures for RIMBP2

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: RIMBP2 is active in the following subcellular-locations: cell junction, cell membrane, synapse.
GO terms: RIMBP2 is active in the following subcellular-locations: cell junction, plasma membrane, synapse.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RIMBP2 has gain in 0 cell-lines, loss in 1 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SW_620, TK_10, SN12C

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SK-N-FI, SK-N-DZ, DMS 454

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For RIMBP2 there are:
4 structures (4 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis