Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

MAST4 (O15021) - Overview - Molecular Target Synopsis

Protein


MAST4, Microtubule-associated serine/threonine-protein kinase 4
Enzyme Classification 2.7.11.1
UniProt O15021

Also Known as MAST4_HUMAN, MAST4, KIAA0303


2W7R
STRUCTURE OF THE PDZ DOMAIN OF HUMAN MICROTUBULE ASSOCIATED SERINE-THREONINE KINASE 4
RCSB/PDB
Inspect Structure
See all 3D Structures for MAST4

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: MAST4 is active in the following subcellular-locations: cytoplasm.
GO terms: MAST4 is active in the following subcellular-locations: cytoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project MAST4 has gain in 0 cell-lines, loss in 3 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: RT4, MS751, HEL

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HUVEC, HMEC, MCF-7

(see details)

RNA Interference


MAST4 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: PCI30, SKBR3. (see details)

3D Structures


For MAST4 there are:
1 structures (2 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


MAST4 has been screened with 6 compounds (6 bioactivities). (see details)