SLC27A2 (O14975) - Overview - Molecular Target Synopsis
SLC27A2, Very long-chain acyl-CoA synthetase
Enzyme Classification 6.2.1.-
Also Known as S27A2_HUMAN, SLC27A2, ACSVL1, FACVL1, FATP2, VLACS
Acyl-CoA synthetase probably involved in bile acid metabolism. Proposed to activate C27 precursors of bile acids to their CoA thioesters derivatives before side chain cleavage via peroxisomal beta-oxidation occurs. In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. Does not utilize C24 bile acids as substrates. In vitro, also activates long- and branched-chain fatty acids and may have additional roles in fatty acid metabolism. May be involved in translocation of long-chain fatty acids (LFCA) across membranes.
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UniProt: SLC27A2 is active in the following subcellular-locations: endoplasmic reticulum membrane, peroxisome membrane.
GO terms: SLC27A2 is active in the following subcellular-locations: cytosol, endoplasmic reticulum, endoplasmic reticulum lumen, endoplasmic reticulum membrane, extracellular exosome, integral component of endoplasmic reticulum membrane, integral component of peroxisomal membrane, peroxisomal membrane, plasma membrane, specific granule membrane.