Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

SLC27A2 (O14975) - Overview - Molecular Target Synopsis


SLC27A2, Very long-chain acyl-CoA synthetase
Enzyme Classification 6.2.1.-
UniProt O14975

Also Known as S27A2_HUMAN, SLC27A2, ACSVL1, FACVL1, FATP2, VLACS

Acyl-CoA synthetase probably involved in bile acid metabolism. Proposed to activate C27 precursors of bile acids to their CoA thioesters derivatives before side chain cleavage via peroxisomal beta-oxidation occurs. In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. Does not utilize C24 bile acids as substrates. In vitro, also activates long- and branched-chain fatty acids and may have additional roles in fatty acid metabolism. May be involved in translocation of long-chain fatty acids (LFCA) across membranes.

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

UniProt: SLC27A2 is active in the following subcellular-locations: endoplasmic reticulum membrane, peroxisome membrane.
GO terms: SLC27A2 is active in the following subcellular-locations: cytosol, endoplasmic reticulum, endoplasmic reticulum lumen, endoplasmic reticulum membrane, extracellular exosome, integral component of endoplasmic reticulum membrane, integral component of peroxisomal membrane, peroxisomal membrane, plasma membrane, specific granule membrane.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project SLC27A2 has gain in 1 cell-lines, loss in 2 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: EKVX, COLO205, SR

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: OCI-M1, SCC-3, HEp-2

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HeLa-S3, A549, MCF-7

(see details)

Screening and Chemistry

SLC27A2 has been screened with 44 compounds (44 bioactivities). (see details)