Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

RAB29 (O14966) - Overview - Molecular Target Synopsis


RAB29, Ras-related protein Rab-7L1
UniProt O14966

Also Known as RAB7L_HUMAN, RAB29, RAB7L1

Rab GTPase key regulator in vesicle trafficking. Essential for maintaining the integrity of the endosome-trans-Golgi network structure. Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (CNS). May play a role in the formation of typhoid toxin transport intermediates during Salmonella enterica serovar Typhi (S.Typhi) epithelial cell infection. Interacts with LRRK2.

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

UniProt: RAB29 is active in the following subcellular-locations: cell membrane, cytoplasm, cytoskeleton, golgi apparatus, perinuclear region, trans-golgi network, vacuole.
GO terms: RAB29 is active in the following subcellular-locations: cis-Golgi network, cytoplasm, cytoskeleton, cytosol, early endosome, extracellular exosome, Golgi apparatus, intracellular vesicle, melanosome, mitochondrion, perinuclear region of cytoplasm, plasma membrane, recycling endosome, symbiont-containing vacuole, trans-Golgi network, vacuole.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project RAB29 has gain in 2 cell-lines, loss in 0 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: OCI-LY-10, OCI-LY-3, TMD8

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HMEC, NHEK

(see details)

3D Structures

At greater than 50% identity similarity to RAB29 there are:
5 structures (10 chains) solved
5 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis