Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RAB29 (O14966) - Overview - Molecular Target Synopsis

Protein


RAB29, Ras-related protein Rab-7L1
UniProt O14966

Also Known as RAB7L_HUMAN, RAB29, RAB7L1

Rab GTPase key regulator in vesicle trafficking. Essential for maintaining the integrity of the endosome-trans-Golgi network structure. Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (CNS). May play a role in the formation of typhoid toxin transport intermediates during Salmonella enterica serovar Typhi (S.Typhi) epithelial cell infection. Interacts with LRRK2.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: RAB29 is active in the following subcellular-locations: cell membrane, cytoplasm, cytoskeleton, golgi apparatus, perinuclear region, trans-golgi network, vacuole.
GO terms: RAB29 is active in the following subcellular-locations: cis-Golgi network, cytoplasm, cytoskeleton, cytosol, early endosome, extracellular exosome, Golgi apparatus, intracellular vesicle, melanosome, mitochondrion, perinuclear region of cytoplasm, plasma membrane, recycling endosome, symbiont-containing vacuole, trans-Golgi network, vacuole.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RAB29 has gain in 2 cell-lines, loss in 0 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: OCI-LY-10, OCI-LY-3, TMD8

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HMEC, NHEK

(see details)

3D Structures


At greater than 50% identity similarity to RAB29 there are:
5 structures (10 chains) solved
5 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis