RAB29 (O14966) - Overview - Molecular Target Synopsis
RAB29, Ras-related protein Rab-7L1
Also Known as RAB7L_HUMAN, RAB29, RAB7L1
Rab GTPase key regulator in vesicle trafficking. Essential for maintaining the integrity of the endosome-trans-Golgi network structure. Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (CNS). May play a role in the formation of typhoid toxin transport intermediates during Salmonella enterica serovar Typhi (S.Typhi) epithelial cell infection. Interacts with LRRK2.
|Protein Length||Ensembl Gene||Ensembl Transcript||Ensembl Protein||Uniprot Isoform|
|203||ENSG00000117280||ENST00000367139, ENST00000235932, ENST00000414729||ENSP00000356107, ENSP00000235932, ENSP00000402910||O14966-1, Q5R7A4-1|
UniProt: RAB29 is active in the following subcellular-locations: cell membrane, cytoplasm, cytoskeleton, golgi apparatus, perinuclear region, trans-golgi network, vacuole.
GO terms: RAB29 is active in the following subcellular-locations: cis-Golgi network, cytoplasm, cytoskeleton, cytosol, early endosome, extracellular exosome, Golgi apparatus, intracellular vesicle, melanosome, mitochondrion, perinuclear region of cytoplasm, plasma membrane, recycling endosome, symbiont-containing vacuole, trans-Golgi network, vacuole.