Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PLD2 (O14939) - Overview - Molecular Target Synopsis

Protein


PLD2, Phospholipase D2
Enzyme Classification 3.1.4.4
UniProt O14939

Also Known as PLD2_HUMAN, PLD2

May have a role in signal-induced cytoskeletal regulation and/or endocytosis. Interacts with EGFR (By similarity). Interacts with PIP5K1B.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: PLD2 is active in the following subcellular-locations: membrane.
GO terms: PLD2 is active in the following subcellular-locations: endoplasmic reticulum membrane, Golgi apparatus, plasma membrane, presynapse.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project PLD2 has gain in 0 cell-lines, loss in 6 cell-lines and no signal in 998 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: M14, MCF7, T47D

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H1703, G61, SNU-216

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HUVEC, A549

(see details)


Screening and Chemistry


PLD2 has been screened with 231 compounds (405 bioactivities), 101 compounds have bioactivities that show binding affinity of <= 500nM (176 bioactivities). (see details)