Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

GEMIN2 (O14893) - Overview - Molecular Target Synopsis

Protein


GEMIN2, Gem-associated protein 2
UniProt O14893

Also Known as GEMI2_HUMAN, GEMIN2, SIP1

The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. Part of the core SMN complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8 and STRAP/UNRIP. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG. Interacts directly with GEMIN5.

5XJR
CRYSTAL STRUCTURE OF THE GEMIN2-BINDING DOMAIN OF SMN, GEMIN2DN39 IN COMPLEX WITH SMD1(1-82)/D2/F/E/G FROM HUMAN
RCSB/PDB
Inspect Structure
See all 3D Structures for GEMIN2

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: GEMIN2 is active in the following subcellular-locations: cytoplasm, gem, nucleus.
GO terms: GEMIN2 is active in the following subcellular-locations: cytoplasm, cytosol, Gemini of coiled bodies, nuclear body, nucleolus, nucleoplasm, nucleus, SMN complex, SMN-Sm protein complex, spliceosomal complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project GEMIN2 has gain in 12 cell-lines, loss in 1 cell-lines and no signal in 992 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H1781, KYSE-140, DMS 79

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HeLa-S3, A549, MCF-7

(see details)

3D Structures


For GEMIN2 there are:
7 structures (7 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis