RIOK3 (O14730) - Overview - Molecular Target Synopsis
RIOK3, Serine/threonine-protein kinase RIO3
Enzyme Classification 220.127.116.11
Also Known as RIOK3_HUMAN, RIOK3, SUDD
Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. May act as an adapter protein essential for the recruitment of TBK1 to IRF3 (PubMed:24807708). Phosphorylates IFIH1 on 'Ser-828' interfering with IFIH1 filament assembly on long dsRNA and resulting in attenuated IFIH1-signaling (PubMed:25865883). Can inhibit CASP10 isoform 7-mediated activation of the NF-kappaB signaling pathway (PubMed:19557502). May play a role in the biogenesis of the 40S ribosomal subunit. Involved in the processing of 21S pre-rRNA to the mature 18S rRNA (PubMed:22418843). Interacts with CASP10 (PubMed:19557502). Interacts with IRF3; RIOK3 probybly mediates the interaction of TBK1 with IRF3 (PubMed:24807708). Associated with 40S pre-ribosomal particles.
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UniProt: RIOK3 is active in the following subcellular-locations: cytoplasm.
GO terms: RIOK3 is active in the following subcellular-locations: cytosol, preribosome.