Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

TRDMT1 (O14717) - Overview - Molecular Target Synopsis

Protein


TRDMT1, tRNA (cytosine(38)-C(5))-methyltransferase
Enzyme Classification 2.1.1.204
UniProt O14717

Also Known as TRDMT_HUMAN, TRDMT1, DNMT2

Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp).

1G55
STRUCTURE OF HUMAN DNMT2, AN ENIGMATIC DNA METHYLTRANSFERASE HOMOLOGUE
RCSB/PDB
Inspect Structure
See all 3D Structures for TRDMT1

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: TRDMT1 is active in the following subcellular-locations: nucleus.
GO terms: TRDMT1 is active in the following subcellular-locations: cytoplasm, nucleoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project TRDMT1 has gain in 3 cell-lines, loss in 6 cell-lines and no signal in 996 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HS578T, SNB_19, HOP_92

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: KMM-1, SiHa, Hs 746T

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HSMM, NHLF

(see details)

3D Structures


For TRDMT1 there are:
1 structures (1 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis