Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PTGES (O14684) - Overview - Molecular Target Synopsis

Protein


PTGES, Prostaglandin E synthase
Enzyme Classification 5.3.99.3
UniProt O14684

Also Known as PTGES_HUMAN, PTGES, MGST1L1, MPGES1, PGES, PIG12

Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Homotrimer.

5T36
CRYSTAL STRUCTURE OF MPGES-1 BOUND TO INHIBITOR
RCSB/PDB
Inspect Structure
See all 3D Structures for PTGES

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
152ENSG00000148344ENST00000340607ENSP00000342385O14684-1

Sub-cellular localization


UniProt: PTGES is active in the following subcellular-locations: membrane.
GO terms: PTGES is active in the following subcellular-locations: endoplasmic reticulum membrane, integral component of membrane, membrane, mitochondrion, nuclear envelope lumen, perinuclear region of cytoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project PTGES has gain in 0 cell-lines, loss in 2 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: NCI_H322M, RXF_393, EKVX

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: RT-112, CAL-12T, RMUG-S

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HeLa-S3, HMEC, A549

(see details)

3D Structures


For PTGES there are:
16 structures (18 chains) solved
16 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


PTGES has been screened with 1697 compounds (2624 bioactivities), 892 compounds have bioactivities that show binding affinity of <= 500nM (1127 bioactivities). (see details)