Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ABCD4 (O14678) - Overview - Molecular Target Synopsis

Protein


ABCD4, ATP-binding cassette sub-family D member 4
UniProt O14678

Also Known as ABCD4_HUMAN, ABCD4, PXMP1L

May be involved in intracellular processing of vitamin B12 (cobalamin). Could play a role in the lysosomal release of vitamin B12 into the cytoplasm. Homodimer or heterodimer.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ABCD4 is active in the following subcellular-locations: peroxisome membrane.
GO terms: ABCD4 is active in the following subcellular-locations: ATP-binding cassette (ABC) transporter complex, endoplasmic reticulum membrane, integral component of membrane, lysosomal membrane, peroxisomal membrane, peroxisome.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ABCD4 has gain in 4 cell-lines, loss in 0 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SW_620, OVCAR_3, SK_OV_3

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: OAW28, NIH:OVCAR-3, RKN

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, K562, HUVEC

(see details)