CIT (O14578) - Overview - Molecular Target Synopsis
CIT, Citron Rho-interacting kinase
Enzyme Classification 18.104.22.168
Also Known as CTRO_HUMAN, CIT, CRIK, KIAA0949, STK21
Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2. Directly interacts with KIF14 depending on the activation state (stronger interaction with the kinase-dead form). Homodimer (By similarity). Interacts with TTC3.
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UniProt: CIT is active in the following subcellular-locations: cytoplasm.
GO terms: CIT is active in the following subcellular-locations: cleavage furrow, cytosol, Golgi cisterna, membrane, midbody, neuronal cell body, nucleus.