Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

DPYSL4 (O14531) - Overview - Molecular Target Synopsis

Protein


DPYSL4, Dihydropyrimidinase-related protein 4
UniProt O14531

Also Known as DPYL4_HUMAN, DPYSL4, CRMP3, ULIP4

Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration. Homotetramer, and heterotetramer with CRMP1, DPYSL2, DPYSL3 or DPYSL5. Interacts with PLEXA1.

5NKS
HUMAN DIHYDROPYRIMIDINASE-RELATED PROTEIN 4 (DPYSL4, CRMP3, ULIP-4)
RCSB/PDB
Inspect Structure
See all 3D Structures for DPYSL4

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
572ENSG00000151640ENST00000338492ENSP00000339850O14531-1

Sub-cellular localization


UniProt: DPYSL4 is active in the following subcellular-locations: cytoplasm.
GO terms: DPYSL4 is active in the following subcellular-locations: cytosol.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project DPYSL4 has gain in 1 cell-lines, loss in 5 cell-lines and no signal in 999 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: U251, HS578T, SNB_19

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MHH-NB-11, SK-N-DZ, SK-N-FI

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, IMR-90, HUVEC

(see details)

3D Structures


For DPYSL4 there are:
1 structures (1 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


DPYSL4 has been screened with compounds ( bioactivities). (see details)