Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
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Interaction Network
Gene Expression
Gene Copy Number Variation
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arc2 (O14241) - Overview - Molecular Target Synopsis

Protein


arc2, Actin-related protein 2/3 complex subunit 2
UniProt O14241

Also Known as ARPC2_SCHPO, arc2, arc34

Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament. Component of the Arp2/3 complex composed of arp2, act2, arc1/p41-ARC, arc2/p34-ARC, arc3/p21-ARC, arc4/p20-ARC and arc5/p16-ARC.

3DWL
CRYSTAL STRUCTURE OF FISSION YEAST ARP2/3 COMPLEX LACKING THE ARP2 SUBUNIT
RCSB/PDB
Inspect Structure
See all 3D Structures for arc2

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
317O14241-1

Sub-cellular localization


UniProt: arc2 is active in the following subcellular-locations: actin patch, cytoplasm, cytoskeleton.
GO terms: arc2 is active in the following subcellular-locations: actin cortical patch, Arp2/3 protein complex, cell division site, cell tip, cytosol, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project arc2 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For arc2 there are:
1 structures (2 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis