Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

trm10 (O14214) - Overview - Molecular Target Synopsis

Protein


trm10, tRNA (guanine(9)-N1)-methyltransferase
Enzyme Classification 2.1.1.221
UniProt O14214

Also Known as TRM10_SCHPO, trm10

S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in cytoplasmic tRNA. Monomer.

4JWF
CRYSTAL STRUCTURE OF SPTRM10(74)-SAH COMPLEX
RCSB/PDB
Inspect Structure
See all 3D Structures for trm10

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
304O14214-1

Sub-cellular localization


UniProt: trm10 is active in the following subcellular-locations: cytoplasm, nucleus.
GO terms: trm10 is active in the following subcellular-locations: cytoplasm, nucleolus, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project trm10 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For trm10 there are:
3 structures (5 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis