Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

F2rl2 (O08675) - Overview - Molecular Target Synopsis

Protein


F2rl2, Proteinase-activated receptor 3
UniProt O08675

Also Known as PAR3_MOUSE, F2rl2, Par3

High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation. Interacts with INSC/inscuteable and GPSM2.

2PUX
13 RESIDUE FRAGMENT OF
PROTEINASE-ACTIVATED RECEPTOR 3
IN THE STRUCTURE OF
CRYSTAL STRUCTURE OF MURINE THROMBIN IN COMPLEX WITH THE EXTRACELLULAR FRAGMENT OF MURINE PAR3
RCSB/PDB
Inspect Structure
See all 3D Structures for F2rl2

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
369O08675-1

Sub-cellular localization


UniProt: F2rl2 is active in the following subcellular-locations: cell membrane.
GO terms: F2rl2 is active in the following subcellular-locations: apical plasma membrane, integral component of plasma membrane, protein-containing complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project F2rl2 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For F2rl2 there are:
1 structures (1 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


F2rl2 has been screened with compounds ( bioactivities). (see details)