Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

tdcD (O06961) - Overview - Molecular Target Synopsis

Protein


tdcD, Propionate kinase
Enzyme Classification 2.7.2.15
UniProt O06961

Also Known as TDCD_SALTY, tdcD, oxd-2

Catalyzes the conversion of propionyl phosphate and ADP to propionate and ATP. It can also use acetyl phosphate as phosphate group acceptor. Homodimer.

4XH5
CRYSTAL STRUCTURE OF SALMONELLA TYPHIMURIUM PROPIONATE KINASE A88G MUTANT, IN COMPLEX WITH AMPPNP AND PROPIONATE
RCSB/PDB
Inspect Structure
See all 3D Structures for tdcD

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
402O06961-1, C9XHG0-1

Gene Copy Number Variation


In COSMIC - Cell Lines Project tdcD has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For tdcD there are:
17 structures (17 chains) solved
15 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

tdcD is solved in complex with the approved drug(s):

AMP/ADENOSINE PHOSPHATE (4FWK_A).

(see details)
Molecular Target 3D Synopsis