Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
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Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

DRB1 (O04492) - Overview - Molecular Target Synopsis

Protein


DRB1, Double-stranded RNA-binding protein 1
UniProt O04492

Also Known as DRB1_ARATH, DRB1, HYL1

Double-stranded RNA-binding protein involved in RNA-mediated post-transcriptional gene silencing (PTGS). Functions in the microRNAs (miRNAs) biogenesis by assisting DICER-LIKE 1 (DCL1) in the accurate processing from primary miRNAs (pri-miRNAs) to miRNAs in the nucleus. Forms a complex with SERRATE (SE) and DCL1 to promote accurate processing of pri-miRNAs by DCL1. Binds and assist DCL1 for accurate processing of precursor miRNAs (pre-miRNA). Indirectly involved in the production of trans-acting small interfering RNAs (ta-siRNAs) derived from the TAS1, TAS2 or TAS3 endogenous transcripts by participating in the production of their initiating miRNAs. Involved with argonaute 1 (AGO1) in the guide strand selection from miRNA duplexes, presumably by directional loading of the miRNA duplex (guide stand and passenger strand) onto the RNA-induced silencing complex (RISC) for passenger strand degradation. Does not participate in sense transgene-induced post-transcriptional gene silencing (S-PTGS). Involved in several plant development aspects and response to hormones through its role in miRNAs processing. Homodimer. Heterodimer with DRB2, DRB4 or DRB5. Interacts with SE and DCL1 (PubMed:15821876, PubMed:16428603, PubMed:16889646, PubMed:20462493). Interacts with RCF3, RS40 and RS41 (PubMed:26227967).

2L2N
BACKBONE 1H, 13C, AND 15N CHEMICAL SHIFT ASSIGNMENTS FOR THE FIRST DSRBD OF PROTEIN HYL1
RCSB/PDB
Inspect Structure
See all 3D Structures for DRB1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
419O04492-1
403O04492-2

Sub-cellular localization


UniProt: DRB1 is active in the following subcellular-locations: nucleus, nucleus speckle.
GO terms: DRB1 is active in the following subcellular-locations: nuclear dicing body, nuclear speck, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project DRB1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For DRB1 there are:
5 structures (7 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis