Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SCD (O00767) - Overview - Molecular Target Synopsis

Protein


SCD, Acyl-CoA desaturase
Enzyme Classification 1.14.19.1
UniProt O00767

Also Known as ACOD_HUMAN, SCD

Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates (PubMed:15907797, PubMed:18765284). Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed:15907797, PubMed:18765284). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids (PubMed:15610069). Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid oxidation (By similarity). Plays an important role in body energy homeostasis (By similarity). Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides (By similarity). May self-associate and form homodimers.

4ZYO
CRYSTAL STRUCTURE OF HUMAN INTEGRAL MEMBRANE STEAROYL-COA DESATURASE WITH SUBSTRATE
RCSB/PDB
Inspect Structure
See all 3D Structures for SCD

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
359ENSG00000099194ENST00000370355ENSP00000359380O00767-1

Sub-cellular localization


UniProt: SCD is active in the following subcellular-locations: endoplasmic reticulum membrane.
GO terms: SCD is active in the following subcellular-locations: endoplasmic reticulum, endoplasmic reticulum membrane, integral component of endoplasmic reticulum membrane, integral component of membrane, membrane, nucleolus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SCD has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SK_MEL_5, BT_549, COLO205

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: BFTC-905, C3A, NCI-H1869

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HeLa-S3, NHEK

(see details)

3D Structures


For SCD there are:
1 structures (1 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


SCD has been screened with 602 compounds (746 bioactivities), 385 compounds have bioactivities that show binding affinity of <= 500nM (452 bioactivities). (see details)