Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PDXK (O00764) - Overview - Molecular Target Synopsis

Protein


PDXK, Pyridoxal kinase
Enzyme Classification 2.7.1.35
UniProt O00764

Also Known as PDXK_HUMAN, PDXK, C21orf124, C21orf97, PKH, PNK

Required for synthesis of pyridoxal-5-phosphate from vitamin B6. Homodimer.

4EOH
CRYSTAL STRUCTURE OF HUMAN PL KINASE WITH BOUND THEOPHYLLINE
RCSB/PDB
Inspect Structure
See all 3D Structures for PDXK

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: PDXK is active in the following subcellular-locations: cytoplasm.
GO terms: PDXK is active in the following subcellular-locations: cytosol, extracellular exosome, extracellular region, nucleoplasm, nucleus, secretory granule lumen, specific granule lumen.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project PDXK has gain in 0 cell-lines, loss in 1 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SK_OV_3, CAKI_1, A498

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SK-OV-3, RT-112, DV-90

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, A549, HMEC

(see details)

RNA Interference


PDXK was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: MDAMB134VI, HUO3N1. (see details)

3D Structures


For PDXK there are:
9 structures (18 chains) solved
7 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

PDXK is solved in complex with the approved drug(s):

TEP/THEOPHYLLINE (4EOH_A, 4EOH_B).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


PDXK has been screened with 13 compounds (13 bioactivities). (see details)