Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

FCN1 (O00602) - Overview - Molecular Target Synopsis


FCN1, Ficolin-1
UniProt O00602

Also Known as FCN1_HUMAN, FCN1, FCNM

Extracellular lectin functioning as a pattern-recognition receptor in innate immunity. Binds the sugar moieties of pathogen-associated molecular patterns (PAMPs) displayed on microbes and activates the lectin pathway of the complement system. May also activate monocytes through a G protein-coupled receptor, FFAR2, inducing the secretion of interleukin-8/IL-8 (PubMed:21037097). Binds preferentially to 9-O-acetylated 2-6-linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage. Homotrimer (PubMed:17897951). Interacts with elastin/ELN. Interacts (via Fibrinogen C-terminal domain) with FFAR2. Interacts with CRP; may regulate monocyte activation by FCN1.

Inspect Structure
See all 3D Structures for FCN1

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization

UniProt: FCN1 is active in the following subcellular-locations: cell membrane, secreted.
GO terms: FCN1 is active in the following subcellular-locations: collagen trimer, collagen-containing extracellular matrix, extracellular region, extrinsic component of external side of plasma membrane, ficolin-1-rich granule lumen, secretory granule lumen.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project FCN1 has gain in 0 cell-lines, loss in 1 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: SK_MEL_5, MCF7, LOXIMVI

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SKM-1, U-937, Hs 746T

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: CD14-positive monocyte, SK-N-SH, NHLF

(see details)

3D Structures

For FCN1 there are:
7 structures (10 chains) solved
4 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

FCN1 has been screened with compounds ( bioactivities). (see details)