Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

FCN1 (O00602) - Overview - Molecular Target Synopsis

Protein


FCN1, Ficolin-1
UniProt O00602

Also Known as FCN1_HUMAN, FCN1, FCNM

Extracellular lectin functioning as a pattern-recognition receptor in innate immunity. Binds the sugar moieties of pathogen-associated molecular patterns (PAMPs) displayed on microbes and activates the lectin pathway of the complement system. May also activate monocytes through a G protein-coupled receptor, FFAR2, inducing the secretion of interleukin-8/IL-8 (PubMed:21037097). Binds preferentially to 9-O-acetylated 2-6-linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage. Homotrimer (PubMed:17897951). Interacts with elastin/ELN. Interacts (via Fibrinogen C-terminal domain) with FFAR2. Interacts with CRP; may regulate monocyte activation by FCN1.

2WNP
M-FICOLIN MUTANT Y271F
RCSB/PDB
Inspect Structure
See all 3D Structures for FCN1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
326ENSG00000085265ENST00000371806ENSP00000360871O00602-1

Sub-cellular localization


UniProt: FCN1 is active in the following subcellular-locations: cell membrane, secreted.
GO terms: FCN1 is active in the following subcellular-locations: collagen trimer, collagen-containing extracellular matrix, extracellular region, extrinsic component of external side of plasma membrane, ficolin-1-rich granule lumen, secretory granule lumen.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project FCN1 has gain in 0 cell-lines, loss in 1 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SK_MEL_5, MCF7, LOXIMVI

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SKM-1, U-937, Hs 746T

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: CD14-positive monocyte, SK-N-SH, NHLF

(see details)

3D Structures


For FCN1 there are:
7 structures (10 chains) solved
4 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


FCN1 has been screened with compounds ( bioactivities). (see details)