GABRP (O00591) - Overview - Molecular Target Synopsis
GABRP, Gamma-aminobutyric acid receptor subunit pi
Also Known as GBRP_HUMAN, GABRP
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. In the uterus, the function of the receptor appears to be related to tissue contractility. The binding of this pI subunit with other GABA(A) receptor subunits alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone. Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and epsilon. A sixth class of subunit: Rho form homomeric GABA receptors that do not appear to coexist with GABA(A) receptor subunits but with GABA(C) receptor subunits. Subunit Pi can also bind this complex.
|Protein Length||Ensembl Gene||Ensembl Transcript||Ensembl Protein||Uniprot Isoform|
|440||ENSG00000094755||ENST00000265294, ENST00000518525||ENSP00000265294, ENSP00000430100||O00591-1|
UniProt: GABRP is active in the following subcellular-locations: cell junction, cell membrane, postsynaptic cell membrane, synapse.
GO terms: GABRP is active in the following subcellular-locations: cell junction, chloride channel complex, GABA-A receptor complex, integral component of plasma membrane, neuron projection, postsynaptic membrane, synapse.