Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RNASET2 (O00584) - Overview - Molecular Target Synopsis

Protein


RNASET2, Ribonuclease T2
Enzyme Classification 3.1.27.-
UniProt O00584

Also Known as RNT2_HUMAN, RNASET2, RNASE6PL

Has ribonuclease activity, with higher activity at acidic pH. Probably is involved in lysosomal degradation of ribosomal RNA (By similarity). Probably plays a role in cellular RNA catabolism.

3T0O
CRYSTAL STRUCTURE ANALYSIS OF HUMAN RNASE T2
RCSB/PDB
Inspect Structure
See all 3D Structures for RNASET2

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: RNASET2 is active in the following subcellular-locations: endoplasmic reticulum lumen, lysosome lumen, secreted.
GO terms: RNASET2 is active in the following subcellular-locations: azurophil granule lumen, endoplasmic reticulum lumen, extracellular exosome, extracellular region, extracellular space, lysosomal lumen, lysosome.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RNASET2 has gain in 1 cell-lines, loss in 6 cell-lines and no signal in 998 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: RXF_393, HL_60, IGROV1

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HCC89, THP-1, 786-O

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: CD20-positive B cell, CD14-positive monocyte, GM12878

(see details)

3D Structures


For RNASET2 there are:
1 structures (1 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis