Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

STK25 (O00506) - Overview - Molecular Target Synopsis

Protein


STK25, Serine/threonine-protein kinase 25
Enzyme Classification 2.7.11.1
UniProt O00506

Also Known as STK25_HUMAN, STK25, SOK1, YSK1

Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration. Homodimer. Interacts with CTTNBP2NL.

4NZW
CRYSTAL STRUCTURE OF STK25-MO25 COMPLEX
RCSB/PDB
Inspect Structure
See all 3D Structures for STK25

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: STK25 is active in the following subcellular-locations: cytoplasm, golgi apparatus.
GO terms: STK25 is active in the following subcellular-locations: cytoplasm, extracellular exosome, Golgi membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project STK25 has gain in 0 cell-lines, loss in 6 cell-lines and no signal in 999 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SN12C, SK_MEL_28, HS578T

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SCLC-22H, PE01, HCC1359

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HUVEC, K562

(see details)

RNA Interference


STK25 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: MDAMB134VI, NY. (see details)

3D Structures


For STK25 there are:
3 structures (3 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


STK25 has been screened with 295 compounds (350 bioactivities), 7 compounds have bioactivities that show binding affinity of <= 500nM (12 bioactivities). (see details)