Molecular Target Synopsis
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BTN3A1 (O00481) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 10/09/2019)
Structural Druggability Help: Help

Chain-based assessment (last updated 10/09/2019)


Chains assessed20
Chains with at least one site assessed as druggable using the strict criteria3
Chains with at least one site assessed as druggable using the relaxed criteria14


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
4V1P_A Butyrophilin subfamily 3 member A1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.27 64 25.5 Yes No
2 empty 2.3 67.6 18 No No
3 empty 1.78 68.3 15.2 No No
4 empty 1.98 69.6 11.7 No No
5 empty 2.23 67 16.9 No No
6 empty 2.06 61.1 16.8 No No
7 empty 2.55 63.2 17.2 No No
8 empty 1.97 62.5 13.6 No No
9 empty 2.09 77.9 10.4 No No
10 empty 2.2 68.3 6.9 No No
4F9P_A Butyrophilin subfamily 3 member A1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.93 71 21.8 Yes Yes
2 empty 1.89 63.7 22.7 No No
3 empty 2.16 69.1 17.3 No No
4 empty 1.79 78.1 12.1 No No
5 empty 1.63 61.9 22.3 No No
6 empty 1.74 58.2 13 No No
7 empty 1.04 96.3 0 Yes No
8 empty 2.3 60.5 10.7 No No
9 empty 2.03 68.8 8.1 No No
10 empty 1.76 62 13.5 No No
4JKW_A Butyrophilin subfamily 3 member A1 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.46 66.7 20.4 No No
2 empty 2.3 62.1 24 No No
3 empty 2.1 66.4 9.7 No No
4 empty 2.71 63.6 11.5 No No
5 empty 2.93 67.9 7.9 No No
6 empty 1.55 76.7 0 No No
7 empty 2.96 59 7.1 No No
8 empty 1.97 61.8 6.6 No No
9 empty 2.14 69.7 8.3 No No
10 empty 2.73 60.2 6.3 No No
4F9L_A Butyrophilin subfamily 3 member A1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.45 58.1 26.1 Yes No
2 empty 2.38 59.7 21.2 No No
3 empty 2.12 70 21.3 No No
4 empty 2.48 66.1 19.2 No No
5 empty 1.58 63.5 17.3 No No
6 empty 2.07 58.3 16.5 No No
7 empty 1.83 66 11.7 No No
8 empty 2.27 64.2 15.3 No No
9 empty 1.56 65.6 11 No No
10 empty 1.44 64 9.3 No No
4K55_A Butyrophilin subfamily 3 member A1 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.44 68.9 14.4 No No
2 empty 2.32 69.1 14.6 No No
3 bound 2.36 54.9 15.2 No No
4 empty 2.02 62.7 18.2 No No
5 empty 2.73 61.1 12 No No
6 empty 2.04 54.9 8.6 No No
7 empty 2.66 64.2 11.9 No No
8 empty 2.85 61.9 8.3 No No
9 empty 1.69 71.7 8 No No
10 empty 2.92 59.5 8.2 No No
5HM7_A Butyrophilin subfamily 3 member A1 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.07 62.5 20.7 No No
2 empty 2.33 63.6 24.1 No No
3 bound 1.9 70.6 18.8 No No
4 empty 2.42 69 20.5 No No
5 empty 1.98 69 13.4 No No
6 empty 2.09 70.4 13.5 No No
7 empty 1.88 64.1 15.7 No No
8 empty 1.95 61.6 20 No No
9 empty 2.41 71.3 12.1 No No
10 empty 2.05 61.9 10.2 No No
5LYG_A Butyrophilin subfamily 3 member A1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.23 65.1 24.6 Yes No
2 empty 1.8 72 13.3 No No
3 bound 1.91 67.6 19.4 No No
4 empty 2.11 66 16.5 No No
5 empty 2.5 66.6 19.5 No No
6 empty 2.18 64.6 15.8 No No
7 bound 2.11 57.4 20.7 No No
8 empty 1.78 52.2 12.6 No No
9 bound 2.28 78.3 10.6 No No
10 empty 1.87 71.1 9.1 No No
4N7U_A Butyrophilin subfamily 3 member A1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.8 68.3 25.7 Yes Yes
2 empty 2.25 63.6 26 No No
3 bound 1.99 69.8 24 No No
4 empty 2.25 61.4 22.1 No No
5 empty 2.53 68.3 19.9 No No
6 empty 1.93 66.5 13.9 No No
7 empty 1.89 60.4 14.4 No No
8 empty 1.95 68.4 13 No No
9 empty 1.89 61.5 10.1 No No
10 empty 2.94 72.2 0 No No
6ITA_A Butyrophilin subfamily 3 member A1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.49 62.8 24.9 Yes No
2 empty 2.66 67.7 18.3 No No
3 empty 1.96 62.2 22.4 No No
4 empty 2.37 74.8 9.5 No No
5 empty 1.88 65.3 11.9 No No
6 empty 2.15 71 12.8 No No
7 empty 2.4 69.4 9.2 No No
8 empty 1.98 68.3 11.5 No No
9 empty 2.24 65.2 12.7 No No
10 empty 2.32 66.4 8.7 No No
6ISM_A Butyrophilin subfamily 3 member A1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.29 60.7 27.3 Yes No
2 empty 1.98 68 26.6 No No
3 empty 2.46 66.4 21.1 No No
4 empty 1.84 65.4 14.5 No No
5 empty 2.02 67.5 20.2 No No
6 empty 2.06 66.4 14.7 No No
7 empty 1.89 62.6 11 No No
8 empty 1.92 70.3 11 No No
9 empty 2.29 72.4 6.9 No No
10 empty 1.82 56.9 8.9 No No
4F9P_B Butyrophilin subfamily 3 member A1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.89 68.9 21 Yes Yes
2 empty 2 72.5 22.1 No No
3 empty 2.11 78.4 14.1 No No
4 empty 2.17 71.3 15.9 No No
5 empty 1.8 64.1 16.5 No No
6 empty 2.16 60.3 18.1 No No
7 empty 1.51 60.2 13.6 No No
8 empty 1.85 71 12.8 No No
9 empty 2.48 69.6 10.1 No No
10 empty 2.48 61.1 15.5 No No
5LYK_A Butyrophilin subfamily 3 member A1 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.43 66.6 18.1 No No
2 empty 1.79 71 14.1 No No
3 bound 1.93 66.3 20.8 No No
4 empty 2.45 67.8 17.2 No No
5 empty 2.08 63.8 17.7 No No
6 empty 2.1 67.6 16.9 No No
7 empty 1.95 62 13 No No
8 empty 2.34 70.5 15.1 No No
9 empty 1.97 69.8 8.4 No No
10 empty 2.49 66.2 7.7 No No
6J06_B Butyrophilin subfamily 3 member A1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.34 62.1 25.5 Yes No
2 empty 1.86 66.6 18.9 No No
3 bound 1.98 71.7 17.6 No No
4 bound 1.9 65.9 16.8 No No
5 empty 2.14 60.8 17.1 No No
6 empty 1.85 67.8 14.4 No No
7 empty 2.01 72.1 17.1 No No
8 empty 2 61.5 17 No No
9 empty 2.3 72.6 11.3 No No
10 empty 2.44 73.2 11.6 No No
4F9L_B Butyrophilin subfamily 3 member A1 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.55 63 22.4 No No
2 empty 1.49 61.2 23.5 No No
3 empty 2.36 65.5 18.8 No No
4 empty 2.01 73.3 15.3 No No
5 empty 2.41 63.2 18.5 No No
6 empty 2.08 59.2 16.1 No No
7 empty 1.74 68.2 12.2 No No
8 empty 1.74 65 13.2 No No
9 empty 1.63 64.4 9.8 No No
10 empty 2.1 65.8 14.2 No No
6J06_C Butyrophilin subfamily 3 member A1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.21 56.2 25.3 Yes No
2 bound 2.24 62.4 18.5 No No
3 empty 1.77 67.9 15.1 No No
4 bound 1.98 67.2 25.7 No No
5 empty 2.29 59.1 15.4 No No
6 empty 1.95 63.3 15.4 No No
7 empty 1.91 68.9 11.7 No No
8 empty 2.28 75.2 10.7 No No
9 empty 1.51 56.4 12 No No
10 empty 2.26 76 10.7 No No
4N7I_A Butyrophilin subfamily 3 member A1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.05 67.5 24.7 Yes No
2 empty 2.37 60.7 26.1 No No
3 bound 1.92 68.5 19.9 No No
4 empty 2.67 68.6 20.3 No No
5 empty 2.06 68.7 15.9 No No
6 bound 2.01 59.2 19.9 No No
7 empty 1.92 65.7 16.7 No No
8 empty 2.47 73.7 12.1 No No
9 empty 2.22 63 9.2 No No
10 empty 1.93 75 6.3 No No
5ZXK_A Butyrophilin subfamily 3 member A1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.31 65.7 24 Yes No
2 empty 1.78 70.6 11.7 No No
3 bound 1.97 67.5 16.3 No No
4 empty 2.26 63.3 21.3 No No
5 empty 2.26 70 14.3 No No
6 empty 2.02 65.2 16.8 No No
7 empty 1.85 61.1 13.5 No No
8 empty 2.39 63.9 12.8 No No
9 empty 2.16 76.2 10.6 No No
10 empty 2.04 63.2 9.6 No No
6J06_A Butyrophilin subfamily 3 member A1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.4 63 25.4 Yes No
2 empty 1.82 68.1 24.7 No No
3 bound 1.9 69 17.1 No No
4 bound 1.97 63.9 16.2 No No
5 empty 2.43 64.7 13.6 No No
6 empty 1.91 62.3 14.8 No No
7 empty 2.39 61.8 15.8 No No
8 empty 2.31 75.8 12.4 No No
9 empty 2.32 61.3 19.6 No No
10 empty 1.8 64.3 10.9 No No
5HM7_B Butyrophilin subfamily 3 member A1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.27 63.6 26.5 Yes No
2 bound 1.89 69.1 24.9 No No
3 empty 2.56 70.2 20.4 No No
4 empty 2.05 62.7 18.2 No No
5 bound 2.06 73.7 12.4 No No
6 empty 1.86 60.8 12.7 No No
7 empty 2.01 72.2 9 No No
8 empty 2.05 63.8 14.3 No No
9 empty 2.22 64.6 10.8 No No
10 empty 1.83 64 9.9 No No
4F80_A Butyrophilin subfamily 3 member A1 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.35 64.6 19.5 No No
2 empty 2.54 64 16.2 No No
3 empty 2.01 63.4 21.8 No No
4 empty 2 66.3 15.6 No No
5 empty 1.73 62.1 12.9 No No
6 empty 2.32 62.5 22.4 No No
7 empty 2.57 65.6 9.2 No No
8 empty 1.76 72.4 7.5 No No
9 empty 2.17 69 9.6 No No
10 empty 2.81 60.3 8.6 No No
Ligand-based Druggability Score: -0.15
Ligand-based Druggability Score Percentile: 78%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


BTN3A1 is involved in 1 interactions in the network.


Druggability
Overall Druggability Percentile: 66.99
Druggability for Cancer Therapeutics: 27.07
Druggability for Other Therapeutics: 82.36
Cancer-Associated
Cancer-associated percentile : 5.93
Network Articulation Point
Is BTN3A1 critical for communication in the network?


Detailed Graph Legend:Help