Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

BTN3A1 (O00481) - Overview - Molecular Target Synopsis

Protein


BTN3A1, Butyrophilin subfamily 3 member A1
UniProt O00481

Also Known as BT3A1_HUMAN, BTN3A1, BTF5

Plays a role in T-cell activation and in the adaptive immune response. Regulates the proliferation of activated T-cells. Regulates the release of cytokines and IFNG by activated T-cells. Mediates the response of T-cells toward infected and transformed cells that are characterized by high levels of phosphorylated metabolites, such as isopentenyl pyrophosphate. Homodimer.

5ZXK
CRYSTAL STRUCTURE OF INTRACELLULAR B30.2 DOMAIN OF BTN3A1 IN COMPLEX WITH HMBPP
RCSB/PDB
Inspect Structure
See all 3D Structures for BTN3A1

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: BTN3A1 is active in the following subcellular-locations: cell membrane.
GO terms: BTN3A1 is active in the following subcellular-locations: external side of plasma membrane, integral component of membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project BTN3A1 has gain in 2 cell-lines, loss in 1 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: RPMI_8226, SF_295, SK_MEL_5

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H596, KMS-27, RPMI 8226

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, AG445

(see details)

3D Structures


For BTN3A1 there are:
15 structures (20 chains) solved
6 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


BTN3A1 has been screened with compounds ( bioactivities). (see details)