Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PDHX (O00330) - Overview - Molecular Target Synopsis

Protein


PDHX, Pyruvate dehydrogenase protein X component, mitochondrial
UniProt O00330

Also Known as ODPX_HUMAN, PDHX, PDX1

Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex. Part of the inner core of the multimeric pyruvate dehydrogenase complex that is composed of about 48 DLAT and 12 PDHX molecules (PubMed:14638692, PubMed:20361979). This core binds multiple copies of pyruvate dehydrogenase (subunits PDH1A and PDHB, E1), dihydrolipoamide acetyltransferase (DLAT, E2) and lipoamide dehydrogenase (DLD, E3) (PubMed:14638692). Interacts with SIRT4 (PubMed:25525879). Interacts with DLD (PubMed:20385101, PubMed:16263718, PubMed:16442803, PubMed:20160912, PubMed:20361979).

6H60
PSEUDO-ATOMIC STRUCTURAL MODEL OF THE E3BP COMPONENT OF THE HUMAN PYRUVATE DEHYDROGENASE MULTIENZYME COMPLEX
RCSB/PDB
Inspect Structure
See all 3D Structures for PDHX

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: PDHX is active in the following subcellular-locations: mitochondrion matrix.
GO terms: PDHX is active in the following subcellular-locations: mitochondrial matrix, pyruvate dehydrogenase complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project PDHX has gain in 8 cell-lines, loss in 1 cell-lines and no signal in 995 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SW_620, SK_MEL_5, U251

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SNU-C1, Detroit 562, SNU-16

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HSMM, HeLa-S3

(see details)

3D Structures


For PDHX there are:
5 structures (13 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis