Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

CDC7 (O00311) - Overview - Molecular Target Synopsis

Protein


CDC7, Cell division cycle 7-related protein kinase
Enzyme Classification 2.7.11.1
UniProt O00311

Also Known as CDC7_HUMAN, CDC7, CDC7L1

Seems to phosphorylate critical substrates that regulate the G1/S phase transition and/or DNA replication. Can phosphorylates MCM2 and MCM3. Forms a complex with either DBF4/DBF4A or DBF4B, leading to the activation of the kinase activity.

5UWQ
13 RESIDUE FRAGMENT OF
CELL DIVISION CYCLE 7-RELATED PROTEIN KINASE
IN THE STRUCTURE OF
CRYSTAL STRUCTURE OF CDC7 NES PEPTIDE IN COMPLEX WITH CRM1-RAN-RANBP1
RCSB/PDB
Inspect Structure
See all 3D Structures for CDC7

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: CDC7 is active in the following subcellular-locations: nucleus.
GO terms: CDC7 is active in the following subcellular-locations: cytoplasm, intercellular bridge, mitotic spindle, nucleoplasm, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project CDC7 has gain in 7 cell-lines, loss in 2 cell-lines and no signal in 996 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: K_562, NCI_H522, OVCAR_8

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HCC38, NCI-H510A, OVCAR-8

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: K562, HeLa-S3, MCF-7

(see details)

RNA Interference


CDC7 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: LM7, RMGI. (see details)

3D Structures


For CDC7 there are:
6 structures (8 chains) solved
4 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


CDC7 has been screened with 561 compounds (739 bioactivities), 396 compounds have bioactivities that show binding affinity of <= 500nM (474 bioactivities). (see details)