Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ATOX1 (O00244) - Overview - Molecular Target Synopsis

Protein


ATOX1, Copper transport protein ATOX1
UniProt O00244

Also Known as ATOX1_HUMAN, ATOX1, HAH1

Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense. Interacts with ATP7B (PubMed:10966647). Interacts with ATP7A (PubMed:21667063).

5F0W
CRYSTAL STRUCTURE OF HUMAN COPPER HOMEOSTATIC PROTEINS ATOX1
RCSB/PDB
Inspect Structure
See all 3D Structures for ATOX1

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


GO terms: ATOX1 is active in the following subcellular-locations: cytosol.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ATOX1 has gain in 0 cell-lines, loss in 1 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SK_MEL_28, M14, SK_MEL_5

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SK-MEL-28, SK-MEL-5, IPC-298

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, A549, HMEC

(see details)

3D Structures


For ATOX1 there are:
15 structures (24 chains) solved
5 are solved in complex with at least one small molecule ligand
3 are solved with an approved drug

ATOX1 is solved in complex with the approved drug(s):

SUC/SUCROSE (1FE0_A, 1FE4_A, 1FEE_A).

(see details)
Molecular Target 3D Synopsis