Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

ATOX1 (O00244) - Overview - Molecular Target Synopsis


ATOX1, Copper transport protein ATOX1
UniProt O00244

Also Known as ATOX1_HUMAN, ATOX1, HAH1

Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense. Interacts with ATP7B (PubMed:10966647). Interacts with ATP7A (PubMed:21667063).

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

GO terms: ATOX1 is active in the following subcellular-locations: cytosol.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project ATOX1 has gain in 0 cell-lines, loss in 1 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: SK_MEL_28, M14, SK_MEL_5

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SK-MEL-28, SK-MEL-5, IPC-298

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, A549, HMEC

(see details)

3D Structures

For ATOX1 there are:
15 structures (24 chains) solved
5 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis