Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

BMPR1B (O00238) - Overview - Molecular Target Synopsis

Protein


BMPR1B, Bone morphogenetic protein receptor type-1B
Enzyme Classification 2.7.11.30
UniProt O00238

Also Known as BMR1B_HUMAN, BMPR1B

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1 and GDF5. Positively regulates chondrocyte differentiation through GDF5 interaction. Interacts with high affinity with GDF5; positively regulates chondrocyte differentiation.

3MDY
CRYSTAL STRUCTURE OF THE CYTOPLASMIC DOMAIN OF THE BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1B (BMPR1B) IN COMPLEX WITH FKBP12 AND LDN- 193189
RCSB/PDB
Inspect Structure
See all 3D Structures for BMPR1B

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: BMPR1B is active in the following subcellular-locations: cell membrane, membrane.
GO terms: BMPR1B is active in the following subcellular-locations: dendrite, HFE-transferrin receptor complex, integral component of plasma membrane, neuronal cell body, plasma membrane, receptor complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project BMPR1B has gain in 0 cell-lines, loss in 1 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: TK_10, KM12, 786_0

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MFM-223, COV434, HCC2911

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: hMSC-AT, SK-N-SH, NHLF

(see details)

RNA Interference


BMPR1B was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: OVISE, SMOV2. (see details)

3D Structures


For BMPR1B there are:
1 structures (2 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


BMPR1B has been screened with 115 compounds (124 bioactivities), 23 compounds have bioactivities that show binding affinity of <= 500nM (26 bioactivities). (see details)