Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

LGALS8 (O00214) - Overview - Molecular Target Synopsis

Protein


LGALS8, Galectin-8
UniProt O00214

Also Known as LEG8_HUMAN, LGALS8

Beta-galactoside-binding lectin that acts as a sensor of membrane damage caused by infection and restricts the proliferation of infecting pathogens by targeting them for autophagy (PubMed:22246324, PubMed:28077878). Detects membrane rupture by binding beta-galactoside ligands located on the lumenal side of the endosome membrane; these ligands becoming exposed to the cytoplasm following rupture (PubMed:22246324, PubMed:28077878). Restricts infection by initiating autophagy via interaction with CALCOCO2/NDP52 (PubMed:22246324, PubMed:28077878). Required to restrict infection of bacterial invasion such as S.typhimurium (PubMed:22246324). Also required to restrict infection of Picornaviridae viruses (PubMed:28077878). Has a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans (PubMed:21288902). Homodimer (PubMed:21288902, Ref.15). Interacts with CALCOCO2/NDP52 (PubMed:22246324). Interacts with PDPN; the interaction is glycosylation-dependent; may participate to connection of the lymphatic endothelium to the surrounding extracellular matrix.

5VWG
GALECTIN-8 N TERMINAL DOMAIN IN COMPLEX WITH METHYL 3-O-[1- CARBOXYETHYL]-BETA-D-GALACTOPYRANOSIDE
RCSB/PDB
Inspect Structure
See all 3D Structures for LGALS8

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: LGALS8 is active in the following subcellular-locations: cytoplasm, cytoplasmic vesicle, cytosol.
GO terms: LGALS8 is active in the following subcellular-locations: cytoplasm, cytoplasmic vesicle, cytosol, extracellular space, membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project LGALS8 has gain in 2 cell-lines, loss in 1 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SR, HCT_15, NCI_H322M

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: ZR-75-30, MDA-MB-453, SUM 52PE

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, K562

(see details)

3D Structures


For LGALS8 there are:
29 structures (45 chains) solved
20 are solved in complex with at least one small molecule ligand
4 are solved with an approved drug

LGALS8 is solved in complex with the approved drug(s):

BGC/DEXTROSE (3AP9_A, 3VKL_A, 3VKL_B, 3VKM_A, 3VKM_B, 4FQZ_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


LGALS8 has been screened with 85 compounds (117 bioactivities), 3 compounds have bioactivities that show binding affinity of <= 500nM (12 bioactivities). (see details)