Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RHOD (O00212) - Overview - Molecular Target Synopsis

Protein


RHOD, Rho-related GTP-binding protein RhoD
UniProt O00212

Also Known as RHOD_HUMAN, RHOD, ARHD

Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Participates in the reorganization of actin cytoskeleton; the function seems to involve WHAMM and includes regulation of filopodia formation and actin filament bundling. Can modulate the effect of DAPK3 in reorganization of actin cytoskeleton and focal adhesion dissolution. Interacts (in GTP-bound form) with DIAPH2 isoform 3, DAPK3, FILIP1 and WHAMM. Interacts with PAK5. Interacts (independent of GTP-loaded status) with ANKFY1.

2J1L
CRYSTAL STRUCTURE OF HUMAN RHO-RELATED GTP-BINDING PROTEIN RHOD
RCSB/PDB
Inspect Structure
See all 3D Structures for RHOD

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: RHOD is active in the following subcellular-locations: cell membrane, early endosome.
GO terms: RHOD is active in the following subcellular-locations: cell cortex, cell division site, cytoplasm, cytosol, early endosome, endosome membrane, intracellular membrane-bounded organelle, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RHOD has gain in 9 cell-lines, loss in 0 cell-lines and no signal in 996 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: NCI_H322M, EKVX, T47D

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SCC-15, CAL-12T, BICR 22

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HMEC, HeLa-S3, A549

(see details)

3D Structures


For RHOD there are:
1 structures (1 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RHOD has been screened with compounds ( bioactivities). (see details)