Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

HRK (O00198) - Overview - Molecular Target Synopsis

Protein


HRK, Activator of apoptosis harakiri
UniProt O00198

Also Known as HRK_HUMAN, HRK, BID3

Promotes apoptosis. Interacts with BCL2 and BCL2L1. Interacts with C1QBP.

2L5B
SOLUTION STRUCTURE OF THE TRANSMEMBRANE DOMAIN OF BCL-2 MEMBER HARAKIRI IN MICELLES
RCSB/PDB
Inspect Structure
See all 3D Structures for HRK

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
116ENSG00000135116ENST00000257572ENSP00000257572
91O00198-1
18ENSG00000135116ENST00000550505ENSP00000465379

Sub-cellular localization


UniProt: HRK is active in the following subcellular-locations: membrane, mitochondrion.
GO terms: HRK is active in the following subcellular-locations: integral component of membrane, mitochondrion.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project HRK has gain in 1 cell-lines, loss in 0 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: TK_10, SK_MEL_5, MALME_3M

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: TK, MHH-PREB-1, WSU-FSCCL

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For HRK there are:
2 structures (2 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis