Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RAB27B (O00194) - Overview - Molecular Target Synopsis

Protein


RAB27B, Ras-related protein Rab-27B
UniProt O00194

Also Known as RB27B_HUMAN, RAB27B

Plays a role in NTRK2/TRKB axonal anterograde transport by facilitating the associaton of NTRK2/TRKB with KLC1 (PubMed:21775604). May be involved in targeting uroplakins to urothelial apical membranes. Interacts with SYTL2, SYTL4, MYRIP and MLPH. Interacts with RPH3A and RPH3A.

2F7S
THE CRYSTAL STRUCTURE OF HUMAN RAB27B BOUND TO GDP
RCSB/PDB
Inspect Structure
See all 3D Structures for RAB27B

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


Gene Copy Number Variation


In COSMIC - Cell Lines Project RAB27B has gain in 3 cell-lines, loss in 16 cell-lines and no signal in 986 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MCF7, HL_60, SK_OV_3

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HEL, NCI-H1869, GR-M

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For RAB27B there are:
1 structures (2 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RAB27B has been screened with compounds ( bioactivities). (see details)