Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

AIP (O00170) - Overview - Molecular Target Synopsis

Protein


AIP, AH receptor-interacting protein
UniProt O00170

Also Known as AIP_HUMAN, AIP, XAP2

May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting., Cellular negative regulator of the hepatitis B virus (HBV) X protein. Interacts with RET in the pituitary gland; this interaction prevents the formation of the AIP-survivin complex.

4AIF
AIP TPR DOMAIN IN COMPLEX WITH HUMAN HSP90 PEPTIDE
RCSB/PDB
Inspect Structure
See all 3D Structures for AIP

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: AIP is active in the following subcellular-locations: cytoplasm.
GO terms: AIP is active in the following subcellular-locations: aryl hydrocarbon receptor complex, cytoplasm, cytosol, membrane, nucleoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project AIP has gain in 12 cell-lines, loss in 0 cell-lines and no signal in 993 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MOLT_4, CCRF_CEM, OVCAR_8

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SNU-387, MFM-223, MDA-MB-134-VI

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HeLa-S3, A549

(see details)

3D Structures


For AIP there are:
3 structures (5 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis