Molecular Target Synopsis
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(I1SB07) - Overview - Molecular Target Synopsis

Protein


, Mu-conotoxin CnIIIC
UniProt I1SB07

Also Known as GM3C_CONCN

Mu-conotoxins block voltage-gated sodium channels (Nav). This synthetic toxin blocks both voltage-gated sodium channels and nicotinic acetylcholine receptor (nAChR). Inhibits the skeletal muscle rNav1.4/SCN4A (IC(50)=1.3 nM) and the brain rNav1.2/SCN2A in a long-lasting manner. A low inhibition is also observed on neuronal mNav1.6/SCN8A and mNav1.7/SCN9A. Modestly blocks nAChR alpha-3/beta-2 subtype (IC(50)=450 nM) (partially reversible) and, to a lesser extent, alpha-7 and alpha-4/beta-2 subtypes (reversible). In vitro, decreases twitch tension in mouse hemidiaphragms (IC(50)=150 nM), and displays a high blocking effect in mouse extensor digitorum longus muscles (IC(50)=46 nM).

2YEN
21 RESIDUE FRAGMENT OF
MU-CONOTOXIN CNIIIC
IN THE STRUCTURE OF
SOLUTION STRUCTURE OF THE SKELETAL MUSCLE AND NEURONAL VOLTAGE GATED SODIUM CHANNEL ANTAGONIST MU-CONOTOXIN CNIIIC
RCSB/PDB
Inspect Structure
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Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
22I1SB07-1

Sub-cellular localization


UniProt: is active in the following subcellular-locations: secreted.
GO terms: is active in the following subcellular-locations: extracellular region, other organism postsynaptic membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For there are:
1 structures (1 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis