Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

lodA (F2JXJ3) - Overview - Molecular Target Synopsis

Protein


lodA, L-lysine 6-oxidase
Enzyme Classification 1.4.3.20
UniProt F2JXJ3

Also Known as LODA_MARM1, lodA

Has antibacterial activity against a wide spectrum of Gram-positive and Gram-negative bacteria including nosocomial isolates of S.aureus and Pseudomonas sp. The antimicrobial activity is due to hydrogen peroxide generated by its lysine oxidase activity. Also has autotoxic activity. Involved in biofilm differentiation; responsible for cell death within microcolonies during biofilm development which is linked to the generation of a phenotypically diverse dispersal population and thus may play a role in colonization. Homotetramer.

2YMW
STRUCTURE OF THE EPSILON-LYSINE OXIDASE FROM MARINOMONAS MEDITERRANEA
RCSB/PDB
Inspect Structure
See all 3D Structures for lodA

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
726F2JXJ3-1

Sub-cellular localization


UniProt: lodA is active in the following subcellular-locations: secreted.
GO terms: lodA is active in the following subcellular-locations: extracellular region.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project lodA has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For lodA there are:
3 structures (6 chains) solved
3 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis