Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

samp1 (D4GUF6) - Overview - Molecular Target Synopsis

Protein


samp1, Small archaeal modifier protein 1
UniProt D4GUF6

Also Known as SAMP1_HALVD, samp1

Functions as a protein modifier covalently attached to lysine residues of substrate proteins, as well as a sulfur carrier in molybdenum cofactor (MoCo) biosynthesis. The protein modification process is termed sampylation and involves the formation of an isopeptide bond between the SAMP1 C-terminal glycine carboxylate and the epsilon-amino group of lysine residues on target proteins. May serve as a proteolytic signal in the cell to target proteins for degradation by proteasomes.

4HRO
CRYSTAL STRUCTURE OF H. VOLCANII SMALL ARCHAEAL MODIFIER PROTEIN 1
RCSB/PDB
Inspect Structure
See all 3D Structures for samp1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
87D4GUF6-1

Gene Copy Number Variation


In COSMIC - Cell Lines Project samp1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For samp1 there are:
3 structures (4 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis