BIO3-BIO1, Bifunctional dethiobiotin synthetase/7,8-diamino-pelargonic acid aminotransferase, mitochondrial
Enzyme Classification 18.104.22.168
Also Known as
BIODA_ARATH, BIO3-BIO1, BIO1, BIO3
Bifunctional enzyme that catalyzes two different reactions involved in the biotin biosynthesis., Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring., Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor. Homodimer.