Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

BIO3-BIO1 (B0F481) - Overview - Molecular Target Synopsis

Protein


BIO3-BIO1, Bifunctional dethiobiotin synthetase/7,8-diamino-pelargonic acid aminotransferase, mitochondrial
Enzyme Classification 6.3.3.3
UniProt B0F481

Also Known as BIODA_ARATH, BIO3-BIO1, BIO1, BIO3

Bifunctional enzyme that catalyzes two different reactions involved in the biotin biosynthesis., Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring., Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor. Homodimer.

4A0F
STRUCTURE OF SELENOMETHIONINE SUBSTITUTED BIFUNCTIONAL DAPA AMINOTRANSFERASE-DETHIOBIOTIN SYNTHETASE FROM ARABIDOPSIS THALIANA IN ITS APO FORM.
RCSB/PDB
Inspect Structure
See all 3D Structures for BIO3-BIO1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
833B0F481-1
512B0F481-5
451B0F481-3
405B0F481-2
287B0F481-4

Sub-cellular localization


UniProt: BIO3-BIO1 is active in the following subcellular-locations: mitochondrion matrix.
GO terms: BIO3-BIO1 is active in the following subcellular-locations: mitochondrial matrix, mitochondrion.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project BIO3-BIO1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For BIO3-BIO1 there are:
4 structures (10 chains) solved
4 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis